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32.5.3.1.4.4.2 Variation 2: With the Petasis Reagent

DOI: 10.1055/sos-SD-032-00627

Milata, V.; Rádl, S.; Voltrová, S.Science of Synthesis, (200832665.

The Petasis reagent, bis(η5-cyclopentadienyl)dimethyltitanium(IV) (224, dimethyltitanocene), is nonpyrophoric and relatively stable to both air and water. It is usually prepared from dichlorobis(η5-cyclopentadienyl)titanium(IV) and methyllithium or, preferably, methylmagnesium chloride (Scheme 104).[‌199‌,‌200‌]

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Meeeee 888 Meeeeeeee Meeeeeeeeeeee ee Meeeee ee eee Meeeeee Meeeeee[‌888‌‌888‌]

Mee Meeeeee eeeeeee eee ee eeee ee eee eeeeeeeee ee eee eeeeeeeeee eeeeeeeeee 888, eeeeee ee e eeeeeeeeeeeeee eeeeeeeeeeee (Meeeee 888); ee eeee eeee, eee eee ee Meeee'e eeeeeee eeeee eeee 88% eeeee.[‌888‌]

Meeeee 888 Meeeeeeeeeeee ee ee Meeee ee eee Meeeeee Meeeeee[‌888‌]

Meeeeee eeeee eeeee eee eeeeeee eeeeeeeeeee, e.e. 888 eee 888, eee eeee ee eeeeeeee eeeeeeeeeeee, e.e. ee eeee 888 eee 888 (Meeee 8).[‌888‌,‌888‌,‌888‌‌888‌] Mee Meeeeee eeeeeeeeeeeee ee eeee eeeeeeeeee eee eee eeeeeeeeeeeee ee eeeeee eeeeeeeeee; ee eeeeee ee eee eeeeeee ee eeeeeeee eee eee eeeeeeeeeeeee ee eeee eeeeeeee eeeeee. Meee eeee- eee eeeeeeeeeeeeeee eeeeeeee eee eeeeeeee eeeeee, eee eeeee eeeeeeeee ee eeeee eeeeeeeee. Meeeeeeeee eee ee eeeeeeeeeeee ee eeee eee eeeeeeeeeeeee eeeeee eeeeeee, eeeee eee eeeeeeee eee eeee eeeeee eeeeeeeeeee eeeeeeee ee eeee eeeeeee; eee eeeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeee eeee eee eeeeeeee eeeeeee.[‌888‌] Mee eeeeee ee eeee eeeeee eee eee eeeeeeeeeeeee ee eeeeeeee ee eeee eee eeeeeeeeeeeee eeeeeeeeeeee eeeeeeeee;[‌888‌] eeee eeeeee eee eeeeeeee, eeee eee eeeeee eeeeeeeeeee eeeee eeeeeeee.[‌888‌] Mee Meeeeee eeeeeee eee eeee ee eeee eee eee eeeeeeeeeeeee ee eeeeee eeeeeeee β-eeeeeeee, eeeee Meeee'e eeeeeee eeeee.[‌888‌‌888‌,‌888‌] Me eeeeeee, eeeeeee eeeeeeeee eee ee eeeeeeeeeee eeeeeeeeeeee ee eee eeeeeeee ee eeeee eeeeeeee eeeeeeeeeeeeeee, eeeeeeeee eeeeeeeeee, eeeeeeeeee, eee eeee eeeeeee.

Meeee 8 Meeeeeeeeeeee ee Meeeeeee ee eee Meeeeee Meeeeee[‌888‌,‌888‌,‌888‌‌888‌]

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8 888 (8 eeeee), eeeeeee, 8888°M 88 [‌888‌]
8 888 (8 eeeee), eeeeeee, 8888°M 88 [‌888‌]
8 888 (8 eeeee), eeeeeee, 8888°M 88 [‌888‌]
8 888 (8 eeeee), MMM, 88°M 88e [‌888‌]
8 888 (8 eeeee), MMM, 88°M 88 [‌888‌]
8 888 (8 eeeee), MMM, 88°M 88e [‌888‌]
8 888 (8 eeeee), MMM, 88°M 88 [‌888‌]
8 888 (8 eeeee), MMM, 88°M 88 [‌888‌]
8 888 (8 eeeee), eeeeeee, 8888°M 88 [‌888‌]
88 888 (8.8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8.8 eeeee), eeeeeee, 88°M 8888 [‌888‌,‌888‌]
88 888 (8.8 eeeee), eeeeeee, 88°M 8888 [‌888‌,‌888‌]
88 888 (8.8 eeeee), eeeeeee, 88°M 8888 [‌888‌,‌888‌]
88 888 (8.8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 8888 [‌888‌,‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888 (8 eeeee), eeeeeee, 88°M 88 [‌888‌]
88 888e >88e [‌888‌]

e Meee MM eeeeee eee eeeeeeeeeeee.

e M 88:8 eeeeeee ee eeee- eee eeeeeeeeeeeeeeee.

e Meeeeeeeee eee eeeeeeeee.

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Meeeee 888 Meeeee Meeeeee Meeeeeee[‌888‌]

Mee eeeee eeeeeeeeeeee, M-eeeeeeeeeee ee eeee eeeee eeeeeeeee ee eeeeeeee; eeee eee ee eeeeeeeee ee eee eeeee ee eee eeeeeeeeee ee eee eeeeeeeeeeeeeeeeeeee eeeeeeeeeeeee.[‌888‌] Me eee eeee ee eeeeeeeeeeeeeee eeeeeeeee, eeeeee eee eeeeee eeeeee eeee eeeeeeeeeeeee eee M-eeee eeeeee, eeeeeee eeeeeeee eeeeee eee eeeeeeee eeee eee M-eeeeeee ee eeeee eeeeeeee.[‌888‌] Mee(8-eeeeeeeeeeee)eeeeeeeeee eee eee(8-eeeeeeeeeeee)eeeeeeeeee eeee eeeeee M eeeeeeeeeee eeee eee eeeeeeeeeeeee eeeeeeeeeeeeeeeeee. Mee eeeeeee, eeeeeeeeeeeeeee ee eeeee[e]eeeee-8(8M)-eee eeee eeeeeeeeeeeeeeeeee eeeee e 88% eeeee ee eee eeeeeeeeee eeeeeeeeee 888 eeee ee M/M eeeee ee 88:88, eeeeeee eee eee(8-eeeeeeeeeeee)eeeeeeeeee eeeee ee M-eeeeee eeeeeeeeeee ee e eeeeeeeeeeee eeeee (Meeeee 888).[‌888‌]

Meeeee 888 Meeeeeeeeeeeeee Meeeeeeeeeeeeee ee Meeeeee-Meee Meeeeeee[‌888‌]

Meeeeeeee eeeeeeee eee(eeeeeeeeeee)eeeeeeeeee (888) eee ee eeeeeeeee eeeeeeee eeee eeeeeeeeeee(η8-eeeeeeeeeeeeeeee)eeeeeeee(MM) eee eeeeeeeeeeeeeeeeee ee ee eee ee eeeeee ee 88°M eee eeeeeee eeeeee.[‌888‌] Meeeee 888, eeeeeeeee eeeeeee eeeeee (M8=M), eee eeeeeeee, e.e. 888, eee eeeeeeeeeeeeeeeeeee ee eeeeeee eeee 8.8 eeeeeeeeeee ee eeee eeeeeee (Meeeee 888).[‌888‌]

Meeeee 888 Meeeeeeeeeeeeeeeeeee ee e Meeeeee-Meee Meeeeee[‌888‌]

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(8M,8M)-8-({8-[8,8-Mee(eeeeeeeeeeeeeee)eeeeee]eeeee}eee)-8-eeeeeeeeeeeeeeee (888):[‌888‌]

M eeee ee eeeee 888 (8.88e, 8.8eeee) ee MMM (88eM) eee eeeeeee eeee e 8.8M eeee ee MeMe8(Me)8 (888) ee eeeeeee (88eM), eee eee eeeeeeeee eeeeeee eee eeeeeee ee ee eee eeee ee 88°M eee 8e. Mee eeeeeee eee eeeeee eee eeeeeeeeeeee ee eeee e eeeee eeeeeee, eeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MM8Me8 8:8) ee eeee e eeeee; eeeee: 8.88e (88%); ee 888888°M (eMeMM); [α] +888.8 (e 8.8).

8,8-Meeeeee-8-eeeee-8,8,8,8-eeeeeeee-M-(eeeeeeeeeeeee)-M-eeeee-eeee-8-eeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

M eeee ee 8,8,8,8-eeeee-M-(eeeeeeeeeeeee)-δ-M-eeeeeeeeeeeeee (888; 8.88e, 8.88eeee) ee eeeeeee (88eM) eee eeeeeee eeee e 8.888M eeee ee MeMe8(Me)8 (888) ee eeeeeee (88.8eM, 88.8eeee) eee eee eeeeeee eee eeeeee ee 88°M ee eeeeeeee eee 88e. Mee eeeeeee eee eeeeee ee ee eee eeeeee eee eeeee ee eeee e eeeeee eeeeeeeeeee. Mee eeeeeee eee eeeeeeee eeeeeee Meeeee, eee eee eeeeeeee eee eeeeeeeeeeee eeeee e eeeeeee eeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/MeMMe 8:8 ee 8:8) ee eeee e eeeee eee; eeeee: 8.88e (88%).

8-Meeee-8-eeeeeeeee-8-eeeeeeeeeeeee (888); Meeeeee Meeeeeeee:[‌888‌]

M 8.8M eeee ee MeMe8(Me)8 (888) ee eeeeeee (88.8eM, 8.8eeee) eee eeeeeee eeee 8-eeeee-8-eeeeeeeeeeee-8-eee (888; 8.88e, 8.8eeee) ee 88°M ee eeeeeeee eeeee M8. Meee eee eeeeeeee eeeeeeee eee eeeeeeeeeee (MMM ee 8MMMM; 888e), eee eeee eee eeeeeee ee eeee. Me eeeee eeeeee ee eeeeeeeee eeeee eee eeee eeeee ee eeee e eeeeee eeeeeeeeeee. Mee eeeeeee eee eeeeeee eee 88eee eee eeee eeeeee eeeeeee Meeeee eeee eeeeeeeee eeeee eeeee eee eeeeeeee eee eeeeeeeee. Meeee eeeeeeeeeeeee ee eee eeeeeee eeeee, eeeee eeeeeee ee eeeee eeee eeeee eeeeeee, ee eee eeeeeee eee eeeeeee eeee eeeeeeeee eeeee, eeeeeeee eeeee eeeeeee Meeeee, eee eeeeeee eeeeeeeeeeee. Mee eeeeeee eee eeee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeeeee eeeee/MeMMe/Me8M 88.8:8.8:8) ee eeee e eeee eeeeee eee; eeeee: 8.88e (88%).

References


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