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Porter, M. J., Science of Synthesis, (2008) 36, 33.
The use of biocatalysis in the oxidation of unactivated C—H bonds to alcohols is widespread, and has been the subject of several reviews.[91–98] Most biocatalytic hydroxylations are carried out with whole-cell systems, primarily due to the complex cofactor requirements of oxidative enzymes and the difficulties encountered in their purification. While a number of bacterial systems have been employed, the most widely used organisms are filamentous fungi,[99] in particular Beauveria bassiana (previously known as Sporotrichum sulfurescens and latterly B. sulfurescens).[100]
Meeeeeeeeeee eeeeeeeeeeeee eee e eeeeee ee eeeeeeeeee eeee eee eeeeeeee eeeeeeeeee. Mee eeeeeeeeeee ee eeeeeee ee eeeeeeeee ee eeee ee eeeeeeee eeeeeeee; eeeeeeeee eeeeeeeee eee eeee eeeeeeee eeeeeeee, eee eeeee eee eeee eeeeeeee ee eee eeeeeeeee ee eeeeee eeeeee ee eeee eeeeeee eeeeeeee. Meeeeeeee ee eeeeeeee eeeeeeeee (eee eeee eeeeee eeeeeee eeee eeeeeeee eeeeeeee) ee eeeeeeeeeeeee eeee. M eeee eeeeee ee eeeeeeeeeeeeeeee ee eeeeeeeeee eeee, eee eeeeeeeee eee eeee eeeeeee eeee eeeeee ee eeeeeeeeeeeeeeeeee. Me e eeeeee, eeeeeeeeeeee ee eeeeeee ee eeeeeeeee eeeeeeeee eeee eee eeeeee eee eeeee ee eeeeeee eeeeeeee eeeeeeeeee.
Meeee eeeeeeeeeeee eeeeeeeee eee eee eeeeeeeee ee ee eeeeee eeeeeeeee, eee eeeee eeeeeeeeeee ee eee eeeeeeeeee ee eeeeeeeeee eee eeee ee eeeeeeeeeeeee ee e eeeeeeeeee eeeeeeeeee eeeee ee eeeeeeeee. Meeeee eeee eeeeee eeee eeee eeeeeeee eee M. eeeeeeee eeee eeeeeeee eeee eee eeee ee eeeeeeeeeeeee eeee eeeeeeeee ee e eeeeeeee ee 8.8 Å eeee e eeeee eeeeeee eeeee ee eee eeeeeeeee (eeeeeeeee ee eeeee).[888,888] Meeeeee, eeeeeeeeeeeee eeee eeeeee ee, eee eeeeeee eeee eeeee eeeeeeeeee eeeeee eee eeee eeeeeeee eee eee eeeeeeeeee eeeeeee ee eee eeeee ee eeee eeeeeeeee.[88] Meeeeeee, eeeeee eeeeeee eeeeeeee eeee M. eeeeeeee eeeeeeee ee eeeee eeee eeeeeeeee eeeeee eeeeeeeeee eeeeeee ee eeeeeeeee eeeeeeeeeeeee, eee e eeeee eeeeeeeee eee ee eeeeeeee ee eee eee (ee eeee) ee eeeee.[888] Meee e eeeeee eeeeeeeeee eeeee eee eee ee eeeeeeeeeee eee eeeee-eeee eeeeeee.
M eeeeeeeee ee eeeeeee eeeeeeeeeeeeeeeee, eeeeeeeee eeeeeeeee ee eeee eeeeeee (Meeee 8, eeeeeee 8 eee 8), eeeeeeeee (e.e., 88; eeeeeee 8–8), eee eeeeeeee eeeeeeee (eeeee 8), ee eeeeeeee ee Meeee 8.
Me eeeeeeeeee eeeeeeeeee eeeeeeeeee ee eee eeeeeeeee ee eeeeeeee; eee eeeeeee, eeeeeeeeeeee (88) ee eeeeeeeee eeee 88α-eeeeeeeeeeeeeeeeeee (88), eeeee ee ee eee ee eeeeeee eeeeeee (Meeee 8, eeeee 8).[888] Meeeeeeee eee eeeeeee eeeeeeee ee e eeeeeee eee ee eeeeeeeeeeee ee eeeeeeeee ee eee eeeeeeeeeee eeeeeeeeeeeee.[888]
Meeee 8 Meeeeeeeeeeee ee Meeeeeeee Meeeeeeee ee Meeee Meeee[888,888–888]
Meeee | Meeeeeee Meeeeeee | Meeeeeeeee | Meeeeee | eee (%) | Meeee (%) | Mee |
---|---|---|---|---|---|---|
8 | M. eeeeee, eM 8.8, 88°M, 888 e | e.e. | 88–88 | [888] | ||
8 | M. eeeeeeee, eM 8.88, 88°M, 88 e | – | 88 | [888] | ||
8 | M. eeeeeeee, 88 e | 88 | 88–88 | [888] | ||
8 | M. eeeeeeee, eM 8.88, 88°M, 88 e | – | 88 | [888] | ||
8 | M. eeeeeeee, eM 8.88, 88°M, 88 e | 88 | 88 | [888] | ||
8 | M. eeeeeeee, eM 8.8, 88–88°M, 888 e | 88 | 88 | [888] | ||
8 | M. eeeeeeeeeeeee, eM 8, 88°M, 888–888 e | – | 88 | [888] | ||
8 | M. eeeeeeee, eM 8.8, 88 e | – | 88 | [888] | ||
8 | M. eeeeeeeee, eM 8.8–8.8, 88°M, 88 e | – | 88 | [888] |
e e.e. = eee eeeeeeee.
Mee eeeee ee eeeeeeeeeeeeeeee eee eeee eeeeeeee ee eee eee ee eeeeeeeee eeeeeeeeeee,[888,888] eeeee ee eee eeeeeeeeeeee ee e eeeeeeee eeee eeeee eee eeeeeeee eeeeeee eeeeeeeee eeeeeeeee ee eee eeeeeeeeee eeeeeeeeee ee e “eeeeeee/eeeeeeeeee eeeee”. Mee eeeeeee (Meeeee 88), eeeeeeeeeeeeeeeeeeeeee eeee ee eee e eeee eeeeeeeee eee eeeeeeeeeeeeeeee eee eee eeeeeeeeeee eeeeeeeeee 88[888] eee ee eeeeeeeee ee eeee eeeeeeeeeeee eeeeee eeee eee eeeeeeeeeeeee eeeeeee 88.[888,888] Meeeeeeeee eeeeeeeeeee ee eee eeeeeeeeeee eeeeeee eee eeeeeee eeee 88.[888]
Meeeee 88 Mee ee Meeeeeeee Meeeeeeeeee ee eee Meeeeeeeeee ee 8-Meeeeeeeeeeeeeeeeeeeeeeeeeeee Meee[888,888–888]
Meeeeeeeeeee Meeeeeeee
8-(8-Meeeeeeeeeee)eeeeeeeee-8-ee (88); Meeeeee Meeeeeeee:[888]
M eeeeeeeeee eeeeee, eeeeeeeeee ee eeee eeeee eeeeee (88 e) eee eeeeeee (88 e) ee M8M eeeeeeee ee eM 8.88 eeee 8 M MeMM (8 M), eee eeeeeeeeee eeee e 88-e-eee eeeeeeeeee eeeeeee ee M. eeeeeeee eee eeeeeeeee eeee eeeeeeeeee eeeeeee ee 88°M eee 88 e. 8-(8-Meeeeeeeeeee)eeeeeeeeee (888 ee) ee MeMM (8 eM) eee eeeee eee eeeeeeeeee eee eeeeeeeee eee 88 e. Mee eeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeee eeee M8M. Mee eeeeeeee eee eeeeeeeeeeee eeeeeeeee eeee MM8Me8 eee 88 e. Mee eeeeeee eeeeeee eee eeeee (MeMM8), eeeeeeeeeeee, eee eeeeeeee ee eeeee eeeeeeeeeeeeee (MeMMe); eeeee: 88 ee (88% eeeee ee eeeeeeeee eeeeeeee eeeeeeee); ee 888–888°M.
References
[91] | Meeee, M. M., Me Meeeeeeeeeeee Meeeeee Meeeeeeee, Meeee, M. M.; Meeeeee, M., Mee.; Meeeeeee: Meeeee, (8888); Mee. 8, e 88. |
[92] | Meeeeee, M. M., Meeeeee Meeeeeeee eeee Meeeeeeee Meeeeee, MMM: Mee Meee, (8888). |
[93] | Meeeeee, M. M., Me Meeeeeeeeeeee, Meeee, M. M., Me.; Meeee-MMM: Meeeeeee, Meeeeee, (8888); Mee. 8e, e 888. |
[94] | Meeeeee, M. M., Meeeeeee, (8888) 88, 888. |
[95] | Meeeeee, M. M., Me Meeeeeeeeeeeeee Meeeeeeeeeee, Meeee, M. M., Me.; Meeeee: Mee Meee, (8888); e 888. |
[96] | Meeeee, M., Me Meeeeeeeeeeeeee Meeeeeeeeeee, Meeee, M. M., Me.; Meeeee: Mee Meee, (8888); e 888. |
[97] | Meeeeee, M. M.; Meeee, M. M., Meee. Meee. Meeeeeeeee., (8888) 88, 888. |
[98] | Meeee, M., Me Meeeeeeeeeeeeeeeee ee Meeeeee Meeeeeeee, Meeeeeee: Meeeee, (8888); e 888. |
[99] | Meeeee, M. M.; Meeeeee, M. M., Meee. Mee. Meee., (8888) 8, 888. |
[100] | Meeeee, M. M., Meeeeeeee, (8888) 88, 888. |
[101] | Meeeee, M. M.; Meee, M. M.; Meeeee, M. M.; Meeeeee, M. M., M. Me. Meee. Mee., (8888) 88, 888. |
[102] | Meeee, M.; Möeeee, M.; Meeee, M., Meeeeeeeeee, (8888) 88, 88888. |
[103] | Meeeeee, M. M.; Meeeee, M. M.; Meee, M. M.; Meeee, M., Meeeeeeeeee, (8888) 88, 8888. |
[104] | Meeeeeee, M. M.; Meeeee, M. M.; Meeeeeee, M. M.; Meeeeee, M. M.; Meeeeeeee, M.; Meeeeee, M. M.; Meeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
[105] | Meeeee, M. M.; Meeee, M. M.; Meeee, M. M.; Meeeeee, M. M., Meeeeeeeeeeeeeeeee ee Meeeeeeeeee Meeeeee Meeeeeeee, Meeeeeee: Meeeee, (8888); e 888. |
[106] | Mee, M. M.; Meee, M. M.; Meeee, M. M.; Mee, M. M.; Meee, M. M.; Meee, M. M.; Meee, M. M., M. Meeeeee. Meeeee., (8888) 88, 88. |
[107] | Meeeeeee, M.; Meeeeeeee, M. M.; Meeee, M.; Meeeeeee, M., Meeeeeeeeee, (8888) 88, 8888. |
[108] | Meeeee, M.; Meeeeeeee, M.; Meeeee, M.; Meeee, M., Meeeeeeeeee: Meeeeeeee, (8888) 8, 888. |
[109] | Meeee, M.; Meeeeeeee, M.; Meeeeee, M. M.; Meeeeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 888. |
[110] | Meeeeeee, M. M.; Meeee, M. M., M. Mee. Meee., (8888) 88, 8888. |
[111] | Meeeee, M. M.; Meeeeee, M. M.; Meeeeee, M. M.; Meeeeee, M. M.; Meeeee, M. M.; Meeeeeeee, M. M.; Meeeeeee, M. M., Meee. Meeeee. (Meeeeeeee), (8888), 8888. |
[112] | Meeeeee, M. M.; Meee, M. M.; Meeeee, M. M.; Meeeeeeee, M. M.; Mee, M., M. Mee. Meee., (8888) 88, 8888. |
[113] | Meeeeeee, M.; ee Meeee, M.; Meeeeeeeeeeee, M.; Meeeeee, M.; Meeeee, M.; Meeeeee, M.; Meeee, M.-M., Meeee. Meee., (8888) 888, 8888; Meeee. Meee. Mee. Me., (8888) 88, 8888. |
[114] | ee Meeee, M.; Meeeeee, M., Meee. Meee. Meeeeeeeee., (8888) 88, 888. |
[115] | ee Meeee, M.; Meeeeee, M.; Meeeee, M.; Meeeeeee, M.; Meeee, M.; Meeee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeee, M.; Meeeee, M., Meeeeeeeeee: Meeeeeeee, (8888) 8, 888. |
[116] | ee Meeee, M.; Meeeeee, M.; Meeeee, M.; Meeeeeee, M.; Meeee, M.; Meeee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeee, M.; Meeeee, M.; Meeeeeee, M., Meeeeeeeeee: Meeeeeeee, (8888) 8, 888. |
[117] | Meeeeee-Meeeeeeeeee, M.; Meeeeee, M.; Meeeeeee, M.; Meeeeeeeeeeee, M.; Meeeeee, M.; Meee, M., Meee. Meeeeeeee. Meeeeeeeee., (8888) 88, 888. |
[118] | ee Meeee, M.; Meeeeee, M.; Meeeee, M.; Meeeeeee, M.; Meeee, M.; Meeee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeee, M.; Meeeee, M., Meeeeeeeeee: Meeeeeeee, (8888) 8, 888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.