Science of Synthesis

Ipaktschi, J.; Saidi, M. R., Science of Synthesis, (2009) 40, 435.

General Introduction

The aminoalkylation of CH-acidic compounds, the Mannich reaction, is a fundamentally important C—C bond-forming reaction in organic synthesis. In its classic direct form, the Mannich reaction is an aminoalkylation of aldehydes or ketones that involves a one-pot reaction of three components: (a) a nonenolizable aldehyde, typically formaldehyde, as a source of an electrophile; (b) ammonia or a primary or secondary amine; and (c) an enolizable carbonyl compound as a source of a nucleophile. The products of this three-component reaction are β-amino aldehydes or ketones.

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References

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• 8.Meeeee-Meee, (8888) 88/8, 888.
• 8.Meeeee-Meee, (8888) M 88e8, 8888.