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Please login to access the full content or check if you have access via40.5.2.1.2.2 Method 2: Alkylation of O-Alkylhydroxylamines
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Geffken, D.; Köllner, M. A., Science of Synthesis, (2009) 40, 1036.
Several methods for direct alkylation of alkoxyamines to give O,N-dialkylhydroxylamines are reported. Solid-phase alkylation of resin-bound 4-hydroxybenzyl bromide 419 with benzyloxyamine affords the O,N-disubstituted hydroxylamine 420, a useful intermediate for the combinatorial synthesis of diverse hydroxamic acids (Scheme 165).[602] O,N-Dibenzylhydroxylamine is obtained from the reaction of benzyloxyamine with benzyl bromide in ethanol in the presence of potassium carbonate.[603]
Meeeee 888 Meeee-Meeee Meeeeeeeee ee e Meeeeeeeeeeeee[888]
Meeeeeee ee eeeeeeeeeee eeee eee 8-eeeeee-8,8-eeeeeee-8M-eeeeee-8-eee 888 eeeeee eeeeeeeeeeeeeeee ee eeee eee M,M-eeeeeeeeeeeee eeeeeeeeeeeee 888, eeeee eeeeee ee e eeeeeeee eeeee ee eeeeeeeee eeeeeeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee 8-Meeeee-8-(eeeeeeeeeee)-8,8-eeeeeeee-8,8-eeeeeee-8M-eeeeee-8-eee[888]
M eeeeeeeee-eeeeeeeee eeeee-eeeeeeeee eeeeeee eeeeeeee ee eeeeeeeeeeeeee, eeeeeeeeeee, eee eeeeee eeeee eee M,M-eeeeeeeeeeeee eeeeeeeeeeeee 888 ee 88% eeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee M-Meeeee-M-(8-eeeeeeeeeee)eeeeeeeeeeeee[888]
M eeeeee ee M-eeeeeeeeeee eeeee 888, eeeeeeeee eeeeeeeeeeeee eee M-eeeeeee eeeeeeee,[888] eee eeeeeeee ee eeeeeeee ee eeeeeeeeeeee eeee α-eeeeeeeeeeeee eeeee ee eeeeeeee eeeeeee ee 8,8-eeeeeee, ee eeeeeeee ee eeeeeeeee eeeeee (Meeeee 888).[888,888]
Meeeee 888 Meeeeeeee ee α-(Meeeeeeeeee)eeeeeeee Meeee[888]
Meeeeeeeeeeeee ee eeeeeeeee ee eeeeeeeeeee ee eee eeeeeeee ee eeeeee(MM) eeeeeeeeeeeeeee ee eeeeeee e eeeeeee ee M-eeeeee-M-eeeeeeeeeeeeeeeeee eee M-eeeeee-M,M-eeeeeeeeeeeeeeeeeeee, ee e eeeee eeeee ee 88:88 (Meeeee 888).[888]
Meeeee 888 Meeeeeee ee Meeeeeeeeeeeee eeee Meeeeeeeeee eee Meeeee(MM) Meeeeeeeeeeeeee[888]
Meeeeeeeee ee (eeeeeeeeeeee)eeeeee 888 eeee M-(8-eeeeeeeeee)eeeeeeeeeee (888) eeeeeee eeeeeeeeeeee 888, eeeee eeee eeeeeeeeeeee eeee eeeeeeeee eeeeeee eeeeeee eeeeeeeeeeeeee M,M-eeeeeeeeeeeee eeeeeeeeeeeeee 888 ee eeeeeeee eeeeee eee MMMM eeeeeeee eeeeeeeeeee (Meeeee 888).[888] M-(Meeeeeeee)eeeeee-8,8-eeeeeee (888, e = 8) ee eeee eeeeeeee ee eeeeeeee ee eeeeeeeeeeeeee eee eeeeeeeee ee eeeeeeeeeeeeeee ee eee eeeeeeee ee eeeeeeeeeeeeeeee eeee.[888]
Meeeee 888 Meeeeeeee ee M-(ω-Meeeeeeeeeee)eeeeee-8,8-eeeeeeee[888]
Meeeeeeeeee, e eeeeee ee eeeeeeeeeeee eeeee eeee M-(8-eeeeeeeeeee)eeeeeeeeeee, eeeeeeee ee eeeeeeeeeeeeee, ee eeee M-eeeeeeeeeeeee-8,8-eeeeeee eeeeeeeeeeeeeeee 888, eeeeee eee eee eeeeeeeee ee eeeeeeeeeeee (Meeeee 888).[888] Meeeeee, ee eeeeee eee eeeeeeee.
Meeeee 888 Meeeeeeee ee M-Meeeeeeeeeeee-8,8-eeeeeee Meeeeeeeeeeeeeee[888]
M-Meeeeeeeeeeeee ee eeeeeeeeeeeeee ee eeeeeeee ee Meeeeee eeeeeeee eeee eeee-eeeee eeeeeeee ee eeee eee eeeeeeeeeeeee eeee-eeeee 8-[(eeeeeeeee)eeeee]eeeeeeeeee (888) ee 88% eeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee eeee-Meeee 8-[(Meeeeeeee)eeeee]eeeeeeeeee[888]
Meeeeeeee, eeeeeeee ee eeeeeeeeeeee ee e eeeee ee α,β-eeeeeeeeeee eeeeee eeeeeee eeeeee β-(eeeeeeeeeeee) eeeeeee 888,[888,888] eeeeee eee eee eeeeeeeeeee ee 8-eeeeeeeeeeeeeeeee[888] ee eeeeeee eeeeeee (Meeeee 888).[888]
Meeeee 888 Meeeeeeee ee β-(Meeeeeeeeeee) Meeeeee[888,888]
References
| [140] | Meeeee, M.; Meeeeee, M., Meeeeeeeeee, (8888) 88, 8888. |
| [415] | Meeee, M., MM 8 888 888, (8888); Meee. Meeee., (8888) 88, 888888. |
| [541] | Meeeeee, M.; Meeeeee, M.; Müeeeeeeee, M.; Meee, M.; Meeee, M.-M.; Meeee, M.; Meeeee, M.; Meeee, M.; Meeee, M., Meeeee. Mee. Meee. Meee., (8888) 88, 8888. |
| [602] | Meeee, M.; Mee, M., MM 88 88 888, (8888); Meee. Meeee., (8888) 888, 8888. |
| [603] | Meeee, M.-M., MM 888 888, (8888); Meee. Meeee., (8888) 888, 88888. |
| [604] | Meeeeee, M. M.; Meeeeeeeeee, M. M., Meeeeeeee, (8888), 88. |
| [605] | Mee, M.; Meeee, M.; Meeeeee, M.; Meee, M. M., Meee. Meeeee. (Meeeeeeee), (8888), 8888. |
| [606] | Meeeee, M.; Meeeeee, M., Meeeeeeeeee, (8888) 88, 8888. |
| [607] | Meeeeee, M.; Meeeeeee, M.; Meeeeee, M., Meee. Meee. Mee. Mee., (8888) 88, 888. |
| [608] | Meeeeeee, M.; Meeeeee, M. M.; Meeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [609] | eee Meee, M.; Meeeeee, M.; Meeeeeee, M.; Meeeeee, M., MM 888 888, (8888); Meee. Meeee., (8888) 888, 88888. |
| [610] | Me, M.; Mee, M.; Meeeeeeeee, M.; Mee, M., Meeeee. Mee. Meee. Meee., (8888) 88, 88. |
| [611] | Meeee, M. M., M. Me. Meee. Mee., (8888) 88, 8888. |
| [612] | Meeeeee, M.; Meeeee, M. M.; Meeee, M. M.; Meeeeeee, M. M., M. Meee. Mee., Meeeee Meeee. 8, (8888), 8888. |
| [613] | Meee, M.; Meee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 88/8, 8888.
- 8.Meeeee-Meee, (8888) M 88e8, 888.
- 8.Meeeee-Meee, (8888) M 88e8, 88.
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