Science of Synthesis

Griesbeck, A. G.; Soldevilla, A., Science of Synthesis, (2008) 43, 359.

Another alternative to the classical Sonogashira reaction uses a zinc species, instead of copper(I), as cocatalyst.[‌59‌] A mixture of zinc(II) chloride and sodium iodide forms the cocatalyst, and the reaction affords arylalkynes ‌28‌ as shown in ‌Scheme 17‌. The process is related to both Sonogashira-type reactions and the Negishi coupling, in which zinc acetylides, stoichiometrically formed, are the reagents.

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References