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Please login to access the full content or check if you have access via Variation 2: Sonogashira Reaction under Microwave-Irradiation Conditions

DOI: 10.1055/sos-SD-043-00304

Griesbeck, A. G.; Soldevilla, A.Science of Synthesis, (200843362.

The Sonogashira reaction can be performed with the assistance of microwave heating. This methodology leads to a dramatic reduction of reaction times. The process can be carried out in homogeneous phase,[‌70‌] under solvent-free (alumina supported),[‌71‌] or solid-phase conditions.[‌72‌] The combination of microwave heating and solid-phase techniques is especially attractive, since heated solid-phase reactions generally require long reaction times, and therefore higher loadings of catalysts.

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