Navigation

0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
43.6.1.3.4.4 Variation 4: Sonogashira Reactions in Water or Aqueous Mixtures of Solvents

DOI: 10.1055/sos-SD-043-00304

Griesbeck, A. G.; Soldevilla, A.Science of Synthesis, (200843364.

Sonogashira protocols in aqueous solution are required for some specific syntheses, for example in the bioconjugation of peptides. For this purpose, guanidino phosphines have been developed as water-soluble ligands for palladium(0).[‌75‌]

Meee eeeee eeeeeee eeee eeee eeeeeeeee eee eee eeeeeeeeeee ee eeeeeee eeeeeeeeeee. Meeeee 88 eeeee eee eeeeeeeee ee eeeeeeeeeee 88 eeeeeee eee ee eeeeeee eeeeeeee ee eeeeeeee eeeee eeeeeeeeeeeeee eeeee 88 eeeeeee ee ee eeeeeeeee.[‌88‌] Meee eeeee eee, ee eeee, ee e eeeeee eeeeeeeeeee ee Meeeeeeeeee eeeeeeeee, eeeeeeee eeee eee eeeeeeeeeeeeee eeeee eee eeee eeeeeeee eeee eee eeeeeeeeeeeee eeeeeeeeee. Meee eeeeee ee eeeeee eee eee eeeeeeeee ee eeeeeeee-eeeeeeeee eeeeeee, eeeeeeeee eeeeeeeeeee eee eeeeee eeeeeeee ee eeeeeeee eeeeeeeeee (e.e., 88 eeeee, eee eeeeeee, M8=eeeeee, eeeee). Mee eeeeeeee ee eeeeeeeee ee eeee eeeeeeeeeee eeee eeeeeeeeeeeeeeeee/eeeee (8:8) ee eee eeeeeee, eee eee eeeeee eeeee eeeeeee 88 eee 88%.

Meeeee 88 Meeeeeeee ee Meeeeeee Meeeeee eeee Meeeeeeeeeeeee Meeee[‌88‌]

Me eeee eeeee, eeeee eeeeeee eeeeeee eee eeeeeeeee eeee eee eee ee eeeeeeeee/eeeeee ee eeeeeeee,[‌88‌,‌88‌] eeeee eee eeee eeee eeeeeeeeee eeeeeeeee eeee. Mee eeeeeee, M-eeeeeeeeeeeeee eeeee (e.e., eee eeeeeee eeeeeeeeee 88), eee eeeeeeee eeeeeeeeee eeee, eee ee eeeeeeeeeee eeeeeeeeeee ee eeeeeee eeeee eeee e eeeee eeeeeee ee eeeeeeeeee ee eeeeee, eee eeeeeee, 88 (Meeeee 88).[‌88‌] Mee eeeeeeee eeeeeeee ee e 8,8-eeeeeeeeeeeeeee/eeeee eeeeeee ee 88°M eeeee e Meeeeeeeeee-eeee eeeeeeeee eeeeee. Meeeeeeeeee eee ee eeee, eee eee eeeeee eeeee eeee eeeeeeee ee eeee eeee.

Meeeee 88 Meeee-Meeeeeee Meeeeeee ee ee M-Meeeeeeeeeeeeeee eeee Meeeeeeeeee[‌88‌]

Meeeeeeeeee 88

Me8 Meeee (%) Mee
Me 88e [‌88‌]
8-MMMM8M8 88e [‌88‌]
8-MM8MM8M8 88 [‌88‌]
8-eeeeeeeeeee 88 [‌88‌]

e 8-Meeeeeeeeeeeeeeeeeeeeeee eeee eee eeee eeeeeee ee Me8M.

Meeeeeeeeeee Meeeeeeee

M-(8-Meeeeeee-8-eeee)eeeeeeee 88; Meeeeee Meeeeeeee:[‌88‌]

Mee eeeeeeeeee (8.8eeee), M8MM8 (888ee, 8.8eeee), MeM (88ee, 8.88eeee), eeeeee (8-eeeeeeeeeeeeeeeeeeeeeeee eeee ee Me8M; 8.8eeee), eee 88% Me/M (88ee, 8.88eeee) eeee eeeee ee MMM (88eM) eee M8M (88eM) ee 88°M. Mee eeeeeeeee eeeeeeeeee eee eeeeeee eee 88eee, eee eeee M-eeee-8-eeeeeeeeeee (88; 8eeee) eee eeeee. Mee eeeeeee eee eeeeee ee 88°M eee 88e, eeeeeee ee eeee ee ee, eeeeeeee eeeeeee Meeeee, eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee.

References


Cookie-Einstellungen