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Please login to access the full content or check if you have access via Method 5: Palladium-Catalyzed Cross Coupling (Copper-Free Sonogashira Reaction)

DOI: 10.1055/sos-SD-043-00304

Griesbeck, A. G.; Soldevilla, A.Science of Synthesis, (200843365.

In conventional Sonogashira reactions using a copper(I) catalyst, symmetrical diyne byproducts are formed via Glaser-type oxidative couplings, complicating the reaction and reducing the yield. Synthetic strategies for direct palladium-catalyzed coupling have been developed to address this problem. These are a convenient and direct route to arylalkynes, and are carried out without the use of a copper cocatalyst.

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