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DOI: 10.1055/sos-SD-043-00383

Sankararaman, S.Science of Synthesis, (200843444.

A modification of the CoreyFuchs synthesis has been reported in which the 1,1-dibromoalkene is directly converted into 1-bromoalkyne 23 by treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide (Scheme 13).[‌27‌] This variation of the CoreyFuchs methodology is very useful considering that 1-bromoalkynes are useful starting materials for the well-known CadiotChodkiewicz coupling for the synthesis of diynes {see Science of Synthesis, Vol.24 [Three CarbonHeteroatom Bonds: Ketene Acetals and YneX Compounds (Section]}.

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