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Zysman-Colman, E., Science of Synthesis, (2010) 45, 159.
One of the most general methods for synthesizing alkylarenes is via a Friedel–Crafts alkylation reaction,[12,13] involving the reversible acid-catalyzed electrophilic aromatic substitution of an alkyl halide or reactive equivalent by an arene.[14] Mechanistic considerations in electrophilic aromatic substitution reactions, including Friedel–Crafts alkylations, have been discussed.[15,16] As the product is inevitably more nucleophilic than the starting material, overalkylation is frequently an issue. A primary disadvantage of this reaction is the potential for rearrangement of the carbenium ion intermediate, resulting in a mixture of alkylated products. Product distribution is governed by the severity of the reaction conditions: temperature, nature of the catalyst, and reaction time all influence the reaction outcome.
References
| [12] | Meeeeee, M.; Meeeee, M. M., M. M. Meee. Meeeeee Meee. Mee., (8888) 88, 8888. |
| [13] | Meeeeee, M.; Meeeee, M. M., M. M. Meee. Meeeeee Meee. Mee., (8888) 88, 8888. |
| [14] | Meeeee, M., Me Meeeeeeeeeeee Meeeeee Meeeeeeee, Meeee, M. M.; Meeeeee, M., Mee.; Meeeeeee: Meeeee, (8888); Mee. 8, e 888. |
| [15] | Meee, M. M., Mee. Meee. Mee., (8888) 8, 888. |
| [16] | Meee, M. M., Meeeeee–Meeeee eee Meeeeee Meeeeeeee, Meeee: Mee Meee, (8888). |
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) 8/8e, 888.
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