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46.5.4.1 Method 1: Cycloisomerization of 1,6-Enynes

DOI: 10.1055/sos-SD-046-00090

Gandon, V.; Thorimbert, S.; Malacria, M.Science of Synthesis, (200946219.

The cycloisomerization of an acyclic 1,6- or 1,7-enyne forms one of the most elegant and reliable methods to construct a conjugated vinylic cycloalkene. Such a procedure directly generates a functionalized product, which can easily be converted into more elaborate compounds.


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