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DOI: 10.1055/sos-SD-047-00294

Chiu, P.; Lam, S. K.Science of Synthesis, (201047739.

The classical version of the ene reaction occurs under thermal conditions, and the temperatures generally required for the reaction between unactivated alkenes as enes and enophiles are quite high, thus limiting its wide synthetic application. Experimentally, the thermal reaction is achieved by flow thermolysis, flash-vacuum pyrolysis, or heating in a sealed tube. Microwave irradiation has been successfully used to accelerate ene reactions[‌9‌] and has been realized for allene,[‌10‌] alkyne,[‌11‌] and carbonyl ene reactions.[‌12‌]

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