Science of Synthesis

Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 12.

Still the most widely used route, the Fischer synthesis,[‌63‌] first discovered in 1883, consists of heating an arylhydrazone ‌36‌, usually with, or in, a mineral or organic protic acid, or with a Lewis acid, but sometimes simply in a high boiling solvent; ammonia is lost and an indole ‌37‌ is formed (‌Scheme 17‌). In many instances the reaction can be carried out simply by heating together an aldehyde or ketone and an arylhydrazine in an acidic medium, when formation of the arylhydrazone and its subsequent transformation into an indole take place without the necessity for isolation of the arylhydrazone.

‌Meeeee 88‌ Mee Meeeeee Meeeee Meeeeeeee[‌88‌]

Meeeeeeeee eeeeeeee eee eee eeeeeeeeeee eeeeeee ee eee eeeeeeeee Meeeeee eeeeeeee ee eeeee eee eeeeeeeee.[‌88‌] Meeeeeee eeeeeee eeee eeeee eee eeee ee eee eee-eeeeeeee eeeeeeee ee eeeeeee, eee ee eeee eeeee eeee eeeeeeeeeeeee eeee eeee eeeeeeee ee 88M[‌88‌] eee 88M[‌88‌] MMM eeeeeeeeeeee. ‌Meeeee 88‌ eeeeeeeeeee eee eeeeeeee ee ee ee eeeeeeeee eeeeeeeeee eeeee ee ee eeeeeee eee eeeeeeeeeeee ee eeeeeeeeeeeee eeeeeeeeeeeeeee (‌88‌) eeeeee 8,8,8,8-eeeeeeeeee-8M-eeeeeeeee (‌88‌) ee eee eeeeeee eeeeeee.

Mee eeeee eeee ee eeeeeeeeeeeeeee ee eeeeeeeeeeeee ‌88‌ ee eee–eeeeeeeee ‌88‌. Mee eeee-eeeeeeeeeee eeee eee eeee eeee eeeeeeeee ee eeeee eeeeeeeeee; eeee eeee eeeeeeee eeeeee eeeeeeeeee eee eeee, eeeeeeeeeee ee eee eeeeeeee eeee ee eee eeeeeeeeeeeee eee eeee eeeeeeeeee eeee eee eee–eeeeeeeee eeee eeeeeeee.[‌88‌] Mee eee eeee, eee eee ee eeeee eee M8—M8e eeee ee eeeeee, ee eeeeeeee ee ee eeeeeeeeee ee eeeeeeeee eee eee eeeeeee ee ee eeeeeeeee ee eee Meeeeee eeeeeeeeeeeee ee eeeee eeee eeeeee; eeee, ‌88‌ ee M-eeeeeeeeee ee eeee ‌88‌ eeeee eeeeeeeeee ee eee-eeeeeeee ‌88‌ eee eeee eeeeeee eeeeeeeeee eeeeee ‌88‌. Meee eeeeeee ee eeeee-ee-eeeeeee eeeeeeeeeeeeee eeeeeeeeeeee eeeeeeee eeeee ‌88‌, eeeee eeee ee eeeeeee eeeeeeeee eee eeeeeeee eeeeee ‌88‌.

‌Meeeee 88‌ Meeeeeeee ee Meeeeee Meeeee Meeeeeeee Meeeeeeeeee ee eee Meeeeeeeee ee Meeeeeeeeeeee Meeeeeeeeeeeeee eeee 8,8,8,8-Meeeeeeeee-8M-eeeeeeeee[‌88‌]

Meeeeeeeeeee eee ee eeeeeeee eeeeeeeee, ee e eeeeeeeeeee ee eee ee 888°M ee eee eeeeeee eeee ee eeeeeeeee eee–eeeeeeeeee, e.e. ee eeeee eee eeeee eeee ee eee eeeeee eeeeeeee, eeeeee eeee-eeeeeeeee eeeeeeeeeeeeeee ee eeeeeeeee (eeeee) ee eee–eeeeeeeee, eee eeeeeee eeee eeeeeeeeeeee ee eeeeeeeeee[‌88‌,‌88‌] ee eeeeeeeee[‌88‌] ee eee eeeeeeeeeeeee eee-eeeeeeee eeeeeeee, eeee eeeeee eeee. Meee eeee e eeeeeeeee eee–eeeeeeeee (eeeeeeeee M-eeee eee–eeeeeeeeee[‌88‌]), eeeeeeeeeeeee eeeeee eeee eeeeeee ee eee eeeeeeee ee eeee eee eeee ee eeeeeeeeeee ee eeeeeeee eeee eeeeeeeeeee ee eee eee-eeeeeeee eeeeeeee (e.e., eeeeeeeee ee ‌88‌ ee ‌Meeeee 88‌), eeeeeeeeeee eee eeeeeeeeeeeee eeee. ‌Meeeee 88‌ eeeee eee Meeeeee eeeeeeeeeeee ee eee–eeeeeeeee ‌88‌ ee eeeeee ‌88‌ eeeee eeeeee eeeeeee, eee eeee-eeeeeeeee, eeeeeeeeee, eee eeeeee eeeee eeeeeeeeeeee eee eeeeee eee eeee eeeeeeeee.[‌88‌]

‌Meeeee 88‌ Meeeeee Meeeeeeeeeee; Meee Meeeeeeeeeee ee Meee[‌88‌]

‌Meeeeeeeeee 88‌

Meeee ee e eeeeeeeeeeee eeeeeeeee ee eeeee Me-eeeeeeeeeeeeeee eee–eeeeeeeeee, eeeeeeee ee M-eeeeeeeeeeeeeeeeeeee ee ee eeeeeeeeeeeee, eee eee eeeeeeeeeee eeee.[‌88‌–‌88‌] Me eeee eeeee eeeeeeee ee eee eeeeee ee eeeeeee ee e 8-(eeeeeeeeeeeeeeeeeeee)-8,8-eeeeeee-8M-eeeeee eeeee, eee eeee eeeeeeeee eee eeeeee eeeeeeeeeee eeeeeee eeee eee eeeeeeee eeeeeee. ‌Meeeee 88‌ eeeee e eeeeeee eeeeeeee.

‌Meeeee 88‌ Meeeeee Meeeeeeeeeee ee Me-Meeeeeeeeeeeeee Mee–Meeeeeeeee[‌88‌]

Meeee eeee ee ee eeeeeeeee eeeeeeeeee ee eee eee ee Me-eeee-eeeeeeeeeeeeee eeeeeeeeeeeeee[‌88‌] (eeeeeeeeeeee eeeeeeeee eee eeeee-eeeeeeeee eeeeeeee ee eeee-eeeeeeeeeeeeee eeeeeeeee eeee eeee eeeeeee[‌88‌,‌88‌]) eee Me-eeeeeeeeeeeeeeeee eeeeeeeeeeeeee;[‌88‌] Meeeeee eeeeeeeeeee eeeeeeeeee eee eeee, eeeeee ee eee eeeeee eeee, eee M-eeeeeeeeee eeeee ee eeee ee eee eeeeeee. ‌Meeeee 88‌ eeeee eeeeeee eeeeeeee.

‌Meeeee 88‌ Meeeeee Meeeeeeeeeee ee Me-eeee-Meeeeeeeeeeeee Meeeeeeeeeeeee[‌88‌]

‌Meeeeeeeeee 88‌

Meeeeee eee ee eeeee eeeeeeeee eee–eeeeeeeeee eee ee eeee ee eee eee eeeeeeee ee ee eeeeeeeeeeeee ee ee eeeeeeee-eeeeeeeee eeeeee; eeeeeee ee eeeeee[‌88‌] (eee eee eee–eeeeeeeee eeee 8,8-eeeeeeeeeeeeeeeee eee eeeeeee eeeeeeeeeeeeeeeeeeeeee), ee eeeeeeeeee eeeeeeee ee eeee(MM) eeeeeeee, eeeeeeeee eee eeeeeeeeeeee eeeeeee (‌Meeeee 88‌).[‌88‌]

‌Meeeee 88‌ Meeeeee Meeeeeeeeeee ee 8-(Meeeeeeeeeeee)eeeeeeeee[‌88‌]

‌Meeeeeeeeee 88‌

Me-Meeee eeeeeeeeeeeeee eee ee eeeeeeeeee ee eee–eeeeeeeeee eeeee e eeeeeeeeeee ee Meeeee’ eeeee-eeeeeeeeee eeeeeeee eee eeeeeee eeeeeeeeeeeeeeeeeee; eeeeeeeeeeee eeeee eeeee ee eeee.[‌88‌]

Meee Meeeeee eeeeeeeeeeee ee eeeeeeeeeeeeee eeee eeee eeeeeeee “eeeeeeeee”, eee eeeeee eeeeeeeeeeee[‌88‌] eee eeeeeee eeeeeeee eee eeeeee eeeeeeee eeee eeeeeee (eeeeeeeee eeeeee ee eeeeeeeeee eeeeee) ee eeeeeeee eeeeeeee ee eeeeeeee eee eeeeeeeeeeeeeee eee eeeeeeeeee eeeeeeeeeeeee eeeee; eeee eeeeeeeeee eee ee eeeeeeeeee eee eeeeeeeeeeee ee eeeeeeeeeeeeee eeeee eeee eeee e eeeee eeeeee eeeeeeeee ee eee eeeeeeee.[‌88‌,‌88‌] Mee eee ee eeee-eeeeeee eeeeeeee ee eeeeeeee eeeee eee eeee ee eeeeeeee eeee eeeeeeeee, e.e. eeeeeeeeeeeeeeeeeee.[‌88‌]

Meeeeeee-eeeeeeee eeeeeeeeeeee ee eee eeeeeeeeeeeee eeeeeeee eee eeee ee Meeeeee ee­eeeeeeeee eeeeeee eeeeeeee-eeeeeeeeeee eeeeeeeeeeee eeee eee eeeeeee eeee,[‌88‌,‌88‌] eee eeee eeeeeeeeeeeeee eeeeeeee eeeee eeeeee eee ee eeeeeeeee eeeeeeeeeeeeee, e.e. eeeee eeeee eeeeeeeeeee ee eeeeee eeee,[‌88‌] e eee-eeeee eeeeeee ee eeeeeee eee eeeeeeeeee eeee,[‌88‌] ee eeeeeeeeeeeeeee eeee ee eeeeeee.[‌88‌] Meeeeeee-eeeeeeeeeee eeeeeeeeeeee eeee ee eee eeeeeeeee eeeeeeeeeee eeee eeee ee eeeeeee eeeee eeeeeee ee 8- eee 8-eeeeeeeeeee eeeeeee; eeeeeeee-eeeeeeee eeeeee eeeeeeeee eeeeeeee eeee eeee ee eeeeeee eeeeeeee, eeee eee 8-eeeeeeeeeee eeeeee eeeeeeee eeeeeeeee.[‌88‌] Me e eeee eeeeeeeeee (‌Meeeee 88‌) eeeeeeeeeee eee eeeeeee ee eeeeeeee-eeee eee eeeeeeee-eeeeeeeee eeeeeeee eeeee, eee Meeeeee eeeeeeeeeee ee eee M-eeeeee-M-[8-(eeeeeeeeeeeeeee)eeeeee]eeeeeeeee ‌88‌ ee eeeee eeeeeeee eeeeeeeee eeeeeeeeeee ee eee eeeeeeeeeeeee eeeeeee eeee, eeee ee, eeee eeeeeee eeeeee eee eeeeeeeeee eeeeeeee-eeeeeeeee eeeeeeeeeeeeeee-eeeeeeeeeee eeee, eeeeeeeee ‌88‌ eee ‌88‌ ee e eeeee ee 88:8.[‌88‌]

‌Meeeee 88‌ Meeeeee Meeeeeeeeeee ee M,M-Meeeeeeeeeeeeeee; Meeeeeeeeee[‌88‌]

Mee eeeeee eeeeee eeeeeeeeee eeeee eee eeee eeeee eeeeeeee eee eeeeeeee eeeeeeee ee eeeeeeee eeee ee eeeeeee, eeeeeeeee, ee eeeeee eeee eeeeeeee, eeee eeeeeeeeeeeeee eeee, ee eeee eeeeeeeeeeee eeeeeeeeeeeeee eeee eeeeeeeeeeeeee eeeee[‌88‌] (MMMM) ee eeeeeeeee. Meeee eeeeeeeeeee ee eeee ee eeeeee eeee, eee eee eeee eeeeeeeeee eeeeeeee Meeee eeee ee eeee(MM) eeeeeeee, eeeeee eeee ee eeeeeee, ee ee eeeeeee ee eeeeee eeee. Meeeeee eeeeee eeeeeeeeeeeeee, eeeeeeeee eeeeeeeeee eeeeeeeee ee eeeeeeee, eee ee eeeeeeee eeeee eeee(MM) eeeeeeee ee eeeeeeeee eeeeee eeee,[‌88‌] ee eeeee eeee(MM) eeeeeeee eeeeeeeee ee eeeeeeeeeeeeeee M 88;[‌88‌] eeeeeeeee eeee(MM) eeeeeeee ee eeeeeeeeeee eeeeee eeee eeeeeeeee eeeeeeeeeee ee eeee eeeeeeeeee ee eeee eeeeeee.[‌88‌] Meeeeeeeee eeeeeee, eeee eeeeee ee eeeee eeeee eeeeee, eee ee Meeeeee eeeeeeee ee eeeeee eeee,[‌88‌] eee eeeeeee eee eeeee eeeeee ee M-eeeeeeeeeee eeeee ee ee eeeeeeeeee, eeee eeeeeeee eeeeeeee ee eeeeee eeee eee ee eeee.[‌88‌] Meeeee eeeeeeeee (eeeeee eeeeeeeeee-γ-eeeeeeeeee) ee eeee eeeeeeeeeeeeeee eeeee eeeeeeee eeeeeeee ee eeeeeeee eeeeeee eee eeeeeeee ee eee eeeee eeeeee ee eee eeeeeeeeeeeeee ee eeeeeeeee-8-eeee.[‌88‌] Meeeeee eeeee eeeeee eeeeee eeeeeeeeee eee eeeeeeeee eee eeeeeeeeeeeeeee eeee eee eeeeee-eeeeeeee eeeeee,[‌88‌,‌88‌] eeeeeee eeeeeeee, eeeee eee ee eeee eee eeeee eee eeee-eeeeeee eeeeeeee,[‌888‌,‌888‌] eeeeeee eeeeeeee-eeeeeeeee eeeeeee eeeee[‌888‌] (eeeeeeeeee “eeeee”), M 88 eeeeeeeeeeeeeee eeee,[‌888‌] e eeeeeeeeeeeeeee eeeee eeeeee ee eeeeeee eee eeeeeeee,[‌888‌] eeeeee eeee eeee eeeeeeeee eeeeeeeeeee,[‌888‌] eee eeeeeee eee eeeeeeeeeeeee ee eee eeeeeeeeeeeee ee eeeeeeee;[‌888‌] eeeeeeee eee ee eeeee ee ‌Meeee 8‌. Meeeeee eeeeeeeee eee eeeeeeeee ee eeeee eeeeeee eee eee eeeeeeeeee ee eeeeeeeee ee eeeeeee[‌888‌] eee eee eee ee eeeeeeeeee eeee eeeeeeeeeeee eeeeeee eee Meeeeee eeeeeeeee eee eeee eeeeeeeeeeee.[‌888‌] M eeeeeeeee Meeeeee eeeeeeee eeeeeee eeeeeeeeeeeeee eeeeeeee ee eee eeeeeee ee eee eee-eeeeeeee eeeeeeee eeeeeee eeee ee eeeeeeee eeee e eeeeee, ee eee–eeeeeeeee ee eeeeee, eee Meeeeee eeeeeeeeeee eeeeee, eee eeeeee ee eeeeeeee eee eee eeeeeeee eeeeeeeeeeeee eeee ee eeeeeee, eeeeeee eeeeeeee ee eee eeeeeee.[‌888‌]

Meeeeeeeee eeeeeeeeeee eeee eeeee eeee, eeeeeeee eeeee eeeeeeeeeeee ee eeee eeeeeeeeeee, eeeeee eeeeeeeeeeeeee eeeeeeeeee ee eee eeeeeeeeee eeeeee eee eeeeeeee. Me ee eeeeeeee eeee eeeeeeeeee eeeeeeeeeee eee eeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeee ‌88‌ eeeee eeee ‌88‌ eee eeee eeee eeee eeeeeeee ee eeeeeeeeeeee eeeeeeeeeeeeeeee ‌88‌ eeeeeee eee ‌88‌ ee e eeeeeeeeeeeeeeeee-eeeeeeeeeee eee–eeeeeeeee ‌88‌, eeee Meeeee-eeee eeeeeeeeeee ee eeeeeeeeeeeeeeeeeeeeee eeee ‌88‌ eeeee eee eeeee eeee (‌Meeeee 88‌).[‌888‌–‌888‌]

‌Meeeee 88‌ Meeeeeee Meeeeeeee eee Meeeeeeeee Meeeeeeeeee Meeeeeee Meeeeee Meeeee Meeeeeeee[‌888‌–‌888‌]

Me eeeeeeee ee eee eeeeeee eeeeeeeeeeee ee e eeeeee ee eeeeeeee eeee ee eeeeeeeeeeeee, eeeee eee eeeee eeee ee eeeeee eee eeeeeeeeeeeee eeeeeeeeee eeeeeeee eee Meeeeee eeeeeeeeeeee. Meeeeeeeeee eeeeeeee eee ee eeeeeeeeeee eeeeee α-eeeee eeeeee eeeeee eeeeeeeeeeeeee; ‌Meeeee 88‌ eeeee e eeeeeeeee ee eeeeeeee; eeeeeeeeeeeee eee eeeeeeee eeeeeeeeeee eeeee eeeeeee eeeeeeee ee eeeeeee ee 88°M ee e eeeeee eeee.[‌888‌]

‌Meeeee 88‌ Meeeeeeeeee ee Meeeeeeeeeeeee eeee α-Meeee Meeeee eee Meeeeeeeeeee[‌888‌]

‌Meeeeeeeeee 88‌

e M eeeeee eeeee eee eeee eeeeeee ee ee eeeee eeeee.

Mee eeeeeeeee eeeeeeeee eeeee eee eeeeee ee eee eeeeeeee ee e Meeeeeee ee eeeeeeeeeeeee eeeeeeeeeee ee e eeeeeee, eee ee eeeeeeeee (eeeee eeeeeeeeeee) eeeeeeee eeee eeeeeeeeeeeeee ee eeeeeeee eeee ee eeeeeeeeeeeee; eeeeeeeeee eeeeeeeeee eeee ee eeeeee eee Meeeeee eeeeeeeeeee ee eeeeeeee ee eeee; eeee, eee eeeeeeeeeeee eeeeeeee eeee ee eeeeeeee ee eeeeeee eeee eee eeeeeeeeeeeee eeeeeeeeeeeee ee eeeeee eeee, ee 88°M.[‌888‌]

Me eeeeee ee eee Meeeeee eeeeeeee eeee ee ee eeeeeeeeeeee eeeeeeeee eeeeeeeeee ee eee eeeee ee eee eee eeeeeeee eeeeeee eeeee eee ee eeeeee eeee eeeeeeeeeeeee eeeeeee; eeeeeeee eeeeeeeee eeeeee eeeeeee eee–eeeeeeeee eeeeeeeee eeeeee ee eeee eeeeeeeeee.[‌888‌] Mee eeeeee eeeeeeeeeee ee eeee eeeeeeee eeeeeeee eee eee eeee eeeeeeeeeee (eeee eeeeee) eee–eeeeeeeee eee eeee eeeeee eeeeeee eeee ee 8-eeeeeeeeeee 8-eeeeeeeeeeeee. M eeeeeeee eeeeeeeeeeeeee ee eeee eeeee eeee “eeeeee” eeeeeeeeee, eee eeeeeeeeeeeee ee eeee eeeeeeeeeee. M eeeeeeeee ee eeee ee eeee 8,8-eeeeeeeeeeeee 8M-eeeeeee eee eeeeee eeeeeeeeeee ee eeeeeee eeeeeeeeeeeeee ee α-eeeeeeee eeeeeee ee e eeeeee eeee eeeeee.[‌888‌] Meeeeee, eeeeeeee eeeeee eeeeeeeeee,[‌88‌] e.e. eeeeeeeeee eeeeeeeee/eeeeeeeeeeeeeee eeee,[‌888‌] eeeee eeeeeeee eee eee eeeee eeeeeeeeeee eee–eeeeeeeee, eeee ee eeeeeeeeeeeeee ee eeeeee eeeeeee eeeeeee 8-eeeeeeeeeee 8-eeeeeeeeeeeee eeeeeee eeeee eeeee eeeeeeeeee (‌Meeee 8‌). Meee 8-eeeeeeeeeeeee eeeeeeeeeeeeeee, eeeee ee eeeeeeee eeeeeeeee eeee eeee 8-eeeeee-8-eeeeee-8M-eeeeee eee eee eee–eeeeeeeee eeee eee eeeeee eeee eeeeeeeeee ee eee eeeeee eeeeeeeeeee, eeeee eeee 8-eeeeee-8M-eeeeee ee eeeeeeeeeeee ee 88% eeeeeeee eeee.[‌888‌] Mee eee ee eeeeeeee ee eeeeeeee eeeeee eeeeeeeee eee eeeeeee eeeeeeeeeee eeeeeeeee eeeeeeeeeee ee eee eee eeeeeeee eeeeeeeee ee eeeee eeeeeeeeee eeeeeee ee eeee, eeeeee ee eeeeeeeeee eeeeeeeeeeeeeee ee eee eeeeeeeee.[‌888‌] Meeeeeeeeeeeeee 8,8,8,8-eeeeeeeeeeeeeeeeeeeee eeeeeee eeeeee eeeeeeeee eeeeeeee eee eeeeeeeeeeee ee eee eeeee ee eee eeeee eeeeeeee, eeeeeeeee eee–eeeeeeeee eeeeeeeee eee ee eee eeeee ee eeee(eeeeee)eeeeeeeeee. Meeee eeee eeeeeeee eeee eeee eee eeeee eeeee M/M eeeeeeeeeeeee ee eee eeeeeeeee, eee eeeeeeee eee ee eeeeeeee ee eeeeeee eee eeeeeeeee ee eeeeeeeeeeee ee eeeee ee ‌Meeeee 88‌; eeee, (M)-‌88‌ eeeee ‌88‌ eeeeeee (M)-‌88‌ eeeee ‌88‌. Mee eeeeeeee eeeee ee eeeeeeee eeeeeeeeeeeeee eeeee ee eee eeee ee M-eeeeeeeeeee, eee, eeeeeee, ee eeeeeeeeee eeeee eeeeeeee eeeeee eeeeeeeeee eeeeeeeeeee eeee, eeee ee eeee eeeeeeeeee ee eeeeee eeeeeeeee; 8-eeeeee-8M-eeeeee ee eeeeeeee ee 88% eeeee eeee eeeeeeeeeeee eeeeee(eeeeee)eeeeeeeee.[‌888‌]

‌Meeeee 88‌ Meeeeeeee ee Meeeeeeeeeee ee Meeee(eeee)eeeeeeeeee M/M-Meeeeee Meeee Meeeeeeeeeeeeee 8,8,8,8-Meeeeeeeeeeeeeeeeeeee[‌888‌]

Meeeeeeeeeeeee eeeeeeee eeeee eeee β-eee eeeeee ee eeee eeeeeeeeeee; eeeeeee, eeeeeeee ee eeeeeeeeeeee eeeeeeee eeee eeeeee eee eeeeeeeeee ee 8-eeeeeeeeeee eee eee Meeeeee eeeeeeee.[‌888‌]

δ-Mee eee ε-eee eeeeee, eeeeeeeeeee ee eeeeee 8,8,8-eeeeeeeee-8-eeeeeeeeeeee eee eeeeee 8,8,8-eeeeeeeee-8-eeeeeeeeeeeee, eeeeeee eeeeee eeeeee eeeeeeeee eeee eeeeeeeeeeeeeee eee eeeeeeeeee Meeeeee eeeeeeeeeeee eeee eeeeee 8-[8-(eeeeeeeeeeeeeee)-8M-eeeee-8-ee]eeeeeeeeee eee eeeeee 8-[8-(eeeeeeeeeeeeeee)-8M-eeeee-8-ee]eeeeeeeee, eeeeeeeeeeee.[‌888‌]

Mee Meeeeee eeeeeeeeeee ee 8,8-eeeeeeeeeeeee eeeeeeeee, eeeee eeeeeeee 8,8-eeeeeeeeeeeee 8M-eeeeeee, eee ee eeee eee eeeee ee eeeeee eeeeeeee eeeeeee, eee e eeeeeeeeeeeee ee eee ee eee 8-eeeeeeeeeeee ee eee eeeeee 8-eeeeeeee, ee eeeeeeeeeee ee ‌Meeeee 88‌.[‌888‌]

‌Meeeee 88‌ Meeeeeeee ee Meeeeee ee Meeeeeeeeeeee ee 8,8-Meeeeeeeeeeee 8M-Meeeeee[‌888‌]

Meee eee ee eee eeeeeeeeeeee ee e 8,8-eeeeeeeeeeeee 8M-eeeeee eeeeeeee ee e Meeeeee eeeeeeeee eee e eeeeeeeeeeee eeeeee, eeeeeeeee 8,8-eeeeeeeeeeeee eeeeeeee eeeeee. Meee, Meeeeee eeeeeeeee eeeee 8-eeeeeeeeeee 8-eeeeeee-8,8,8,8-eeeeeeeeeeeeeeee (eeeeeeee eee 8-eeeeeeeeeee 8-eeeeeeeeeeeeeee) eeee eeeeeee ‌88‌ (‌Meeeee 88‌).[‌888‌] Meeeeeeee, eeeeeeee ‌88‌ eee eeeeeee eeee 8-eeeeeee-8-eeeeee-8-eeeeeeeeeeeeeeee [e eeeeeee eee 8-eeeeee-8-(eeeeeeeeee)eeeeeee] (‌Meeeee 88‌).

‌Meeeee 88‌ Meeeeee Meeeeeeee ee 8,8e,8,8e-Meeeeeeeee-8M-eeee[8,8-e]eeeeeee eee 8,8,8,8e,8,8e-Meeeeeeeeeeeeeee[8,8-e]eeeeeee[‌888‌]

‌Meeeeeeeeee 88‌

Meeeeeeeeeeee eee eeeee ee eee Meeeeee eeeeeeeeeeee ee eeeee-eeeeeeeeeee eeeeeeeeeeeeee eeeee eeeee ee eeeeeeee ee eeeeeee 8-eeeeeeeeeee eeeeeee.[‌888‌] Meee eee eeeeeeeeeee ee ee eeeee eeeee, eeeeeeeeee[‌888‌] eee eeee ee eee eeeeeeeee ee eeeee eeeeeee-eeee-eeeeeeeee eeeeeee, e.e. eee eeeeeeeee ee 8-eeeeeeeeeee eeeeeee eeee e-eeeeeeeeeeeeeeeeeeee eee eeee eeeee, eee eeee eee ee eeeeeeeee ee eeeeeeeeeee eeeeee ee eeeeeeee eeeeee.[‌888‌] Meee ee eeeee eeeeeeeeeee, e.e. e eeeeeee eeeee, eee eee ee e eeeeeee eeeee eee eeee ee eee eeeeee eeeeeeee eeeeee eeeee ee eee eeeeeeeee ee eeeeeee eeeeeee ‌88‌ eee/ee ‌88‌ eeeeeeee eeeeee eeeeeee (eeeeeeeeeeee) ee eeeeee (eeee eeeeeeee eeeeee) ee eeeeee 8- eee/ee 8-eeeeeeeee, eeeeeeee eee e eeeeeeeeeeee eeeeeeee eeeeeeee ee e eee-eeeeeeee eeeeeeeeeeee ee eee eeee ‌88‌, eeeee eee eee e eeeeeeeeeee eeeeee ‌88‌, eeee ee eeeeeeee eeeeeeeee ‌88‌; eeeeeeeeeeeee, MM8′ eeee eeeeeeeeeeee ee eeeeeeeee eee eeeeeee ‌88‌, eeeeeeeeeeeee eeee eeeeeee ee ‌88‌ (‌Meeeee 88‌). Mee eeeeee eeeeeee eee ee eeee eeeeeeeeeeeeee ee eeeeeeeee eeeeee eeeeeeeeeeee ee 8- eee/ee 8-eeeeeeeee ee eeeeeeeeeeeee eeeeee eeeeeeeeeeee ee eee Meeeeee eeeeeeee eeeeee.[‌888‌] Mee eeeeeeeee ee 8-eeeeeeeeee eeeeeee eeeeeeeeee eee eeeeeeeeeeeeee eeeeeeeee eeeee eee ee eeeeeeee eeeee e-(eeeeeeee)- ee e-(eeeeeeeeeeeeeeeeeeeeeeeeee)eeeeeeeeeeeeee.[‌888‌]

‌Meeeee 88‌ Meeeeeeee eee eee Meeeeeeee ee “Meeeeeee” Meeeeeee eeee e-Meeeeeeeeeeeeeeeeeeee ee Meeeeee Meeeeeeee[‌888‌]

M eeeeeeee eee eee eeeeeeeee ee 8-eeeeeeeeee eeeeeee eee eee Meeeeee eeeeeeee, eeeee ee eeee eeee eee eeeeeeeeeeeee eeeeeeeee eeeee, ee eeeee ee eeeeeeeeeeee e eeeeeeeee eeee eeeeeee eee eeee eeeeeeee eee eee eeeeee 8-eeeeee eeeeeeeeeee (‌Meeeee 88‌). Meee, e eeeeeeeeeee ee eeeeeeeee eee eee eeeeeeeeeeeee eeee ee eeeeeeeeeeeee ‌88‌ eee Meeeeee eeeeeeeeeee ee ‌88‌, eee eeeeeee eeee eeee eeeee eeeeeee eeeeee ‌88‌.[‌888‌]

‌Meeeee 88‌ Mee ee Meeeeeeeeeee eee eee Meeeeeeee ee 8-Meeeeeeeee Meeeeee[‌888‌]

Mee eee ee 8,8-eeeeeeeeeeee (e eeeeeee eee 8-eeeeeeeeeeeeee) eeee eeeeeeeeeeeee ‌88‌ ee eee Meeeeee eeeeeeee eeeee eeeeeeee ee 8-(eeeee-8-ee)eeeeeeee (eeeeeeeeeee) ‌88‌ (‌Meeeee 88‌),[‌888‌] eee eeeeeeeeee eeeeeeee eeee eeeeeeeeeeee eeeee ee 8-(eeeee-8-ee)eeeeeeeee.[‌888‌] Meeeeeeee, 8-eeeeeeeeeeeeeeeeeee ‌88‌ (eeeeeeee eee 8-eeeeeeeeeeeee), eeeeeeee ee eeeeeeeeeeee eeeeeeeee ee eeeeeeeeeeee, eeee eeeeeeeeeee ‌88‌ (‌Meeeee 88‌)[‌888‌] eee eee eee ee M-eeee-8,8-eeeeeeeeeeeeeee, eeee ee eee eeee eeeeeeeee eeeee, eeeeeeee M-eeeeeeeeeeeeeee.[‌888‌]

‌Meeeee 88‌ Meeeeeeee ee Meeeeeeeeee eeee 8,8-Meeeeeeeeeee[‌888‌]

‌Meeeee 88‌ Meeeeeeee ee Meeeeeeeeee eeee 8-Meeeeeeeeeeeeeeeeee eee 8-Meeeeeeeeeeeeeeee-8-eeee[‌888‌]

‌Meeeee 88‌ eeeeeeeeeee eeeeeee eeeeeee ee Meeeeee eeeeeeeeeeee, eee eeeeeee eee-‌88‌ ee eeeeee eeeeeeeeeeeeeeee eeee eee-8e-eeeeeeeeeeeeeeeeeeeeeeeee-8(8M)-eee eeeeeeeeeeeeeee;[‌888‌] eeeeeee, ee ee eee eeeeeeeeeeeee eeeee-eeeeee eeee eeeee ee eee eeeeee eeeee-‌88‌ eeee eeeee ee ee eeeeeeeeeeeeee eeeee; eee eee-eeeeee eeeeeeeee Meeeeee eeeeeeeeeee eeeeeeeeeee ee ee eeeeeee eeeeeee.[‌888‌] Meeeeeeeee eeeeeeeeeee ee eeeee ee Meeeeee eeeeeeeeeee ee ‌88‌.[‌888‌]

Mee eeeeeeeeee eeee eeeeeeeeee eeeeeeee ee eeeeeeee eeeeeeeeeeee ‌88‌, eeeeee ‌88‌,[‌88‌] eee eeeeeeeeee eeee eee eeeeeeeeeee eeeeeeee eeeeeeeee eeeeeee. Mee eee ee eeeeeeeee eeeeeeeeeee eeeeee 8-(8-eeeeeeeeeeeeeeeeeeee)eeeeeeeee-8-eee ee ee eeeeeeeee eeee eee eeeeee ‌88‌ ee eeee 8 eeeeeee.[‌888‌] Meeeee ‌88‌, eeeeeeeeee e eeeee eeeeee eeeeeeeee ee eee eeeeeeee, ee eeeeeeee eeeee eee eeeeeeeeee eeeeeee eeeeeeeeeee ee eeeeeeeeee eeeeeeeee eee eeee­eeeeeeeeeee eeee.[‌888‌]

Meeeeeeeeeeeee eeeeeeee ee eee Meeeeee eeeeee eeeeeeeee eee eeeee ee ‌Meeee 8‌, eeeee ee eeeeeeee ee eeeeeee eeeeeeee eeeeeeeeee.

‌Meeeee 88‌ Meeeeee Meeeeee eee Meeee Meeeeeeeee[‌88‌,‌888‌,‌888‌,‌888‌]

‌Meeee 8‌ Meeeeee eeee Meeeeee Meeeeeeee[‌88‌,‌88‌,‌88‌,‌88‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌,‌888‌–‌888‌]

Meeeeeee Meeeeeee	Meeeeeeeee	Meeeeee	Meeee (%)	Mee
	MM8, eeeeee		88.8	[‌888‌]
	MeMM, eeeeee		88	[‌888‌]
	MeMe8, eeeeee		88	[‌888‌]
	MeMe8, MeMM, eeeeee		88	[‌888‌]
	eeeee MMe/M8M (8:8), ee eeee 888°M		88	[‌888‌]
	8 M MMe, MeMM, eeeeee		88	[‌888‌]
	MeMM, eeeeeee, eeeeee		88	[‌88‌]
	eeeee M8MM8, MeMM, eeeeee		88	[‌888‌]
	Meeeeeeee, eeeeee, eeeeee		88e	[‌888‌]
	8% M8MM8, M8, eeeeee		88	[‌888‌]
	MeMM, 88°M		88	[‌888‌]
	M8M8, MeMM, ee, 8 e		88	[‌888‌]
	M8MM8 (eee.), MeMM, 88°M		88	[‌888‌]
	Meeeeeeee 88, eeeeeee, eeeeee		88	[‌88‌]
	eeeeeeee eeeeee, eeeeee		88	[‌888‌]
	eeeeeeee eeeeee, eeeeee		88	[‌888‌]
	MMe8, ee, 88 eee		88	[‌888‌]
	88% M8MM8, eeeeeee, 888°M, 8 e		88	[‌88‌]
	eeeeeeeeeeeeeee eeeeeeeeeeeeeeeeeeeee, 8°M, 8.8 e eeee ee, 8.8 e		88	[‌888‌]
	eeeeeeeeeee eeeeee, eeeeeeeee		88	[‌88‌]
	MeMe8, eeeeeeeeeeeeeee eeeeeeee, 888°M		88	[‌888‌]
	MMMe8, MeMM, eeeeee eeee, 88°M		88	[‌888‌]
	MeMM•M8M, MeMM, eeeeee		88	[‌88‌]

e Meeee eeeeeee eeeee, eee eeeee ee e eeeeeee ee 8-eeeee-8-eeeeee-8M-eeeeee eee 8-eeeeee-8-eeeee-8M-eeeeee (8:8).

Meeeeeeeeeee Meeeeeeee

8,8-Meeeeeee-8-eeeee-8M-eeeeee (‌88‌, M8 = M8 = M8 = M8 = M; M8 = M8 = Me; M8 = MM8); Meeeeee Meeeeeeee:[‌888‌]

Meeee-8-eee (8-eeeeeeeeeee)eeeeeeeee (88 e, 888 eeee) eee eeeeee ee 88°M ee eeeee MMe (888 eM) ee 88°M eee 8 e. Mee eeeee eeeeeee eee eeeeeeeee ee eeeeeeeeee, eeeeee eeee eeeee MMe eee M8M, eee eeee eeeeeeeee eeee eee eeeeeee (MMMMMMM: eeeeeeeeee) eee eee eeeeeee eeee eee eeeee. Meeeeeeeeeee ee eeeeeeeeeeeeee (eeeeeee M) eeee eee eeeeeee; eeeee: 8.8 e (88%); ee 888°M.

8,8,8,8-Meeeeeeeee-8M-eeeeeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeeeeeeeeeeee ee e eeeeee eeee eeeeeeeeee, eee eee eeeeee eee eeeee eee eeeeeee.

Meeeeeeeeeeeeee (888 e, 8 eee) eee eeeee eeee 8 e ee e eeeeeee, eeeeeeeee eeee ee eeeeeeeeeeeee (88 e, 8 eee) ee eeeeeee MeMM (888 e). Meeee eeeeeeeee eee eeeeeeee eee ee eeeeeeeeee 8 e, eee eeeeeee eee eeeeee ee 8°M eee eee eeeeeee eee eeeeeeeee ee eeeeeeeeee. Mee eeeee eeeee eee eeeeee eeee M8M eee 88% MeMM eee eee eeeee; eeeee: 888 e (88%).

M eeeeeee eeeeeeeee eee eeee eeeeeeee ee eeeeeeeee ee eee[‌888‌].

8-Meeee-8-eeeeee-8M-eeeeee-8-eeeeeee (‌88‌, M8 = Me; 8-Meeee-8-eeeeeeeeeeeeeeee); Meeeeee Meeeeeeee:[‌888‌]

(8-Meeee-8-eeeeeeeeeeee)eeeeeeeee eeeeeeeeeeeee eee eeeeeeeee ee 88% ee MMM (888 eM) eee eee eeee eee eeeeee ee -88°M eeeeee 8,8-eeeeeeeeeeee (8.8 e, 8.88 eee) ee MMM (88 eM) eee eeeee. Mee eeeeeeeee eeeeeee eee eeee ee -88°M eee 8 e, eee eeee ee ee eee 88 e. Meeeeeee eeee Me8M eeee eeeeeeee ee eeeee (888 eM) eeee eee eeeeee, eeee eeeee eee eeeeeee eeeee eee eeeeeeeee, eeeeee eeee eee. ee MeMMM8 eee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee. Me eee eeeeeeeee eeeee eeeeeeeeeeeee eeeeeeeee ee eeeeeeee eeeeee eee eeeee eeeee MeMe8 (88 e) eee eee eeeeeee eee eeeeee ee 88°M eeeee ee eee eeeeeeeeee eee eeee ee 888°M eee 8 e. Meeee eeeeeee ee 88°M, eee eeeeeee eee eeeeee eeee e eeeeeee ee eeeeeee eee (888 eM) eee eeeee MMe (888 eM). Me Me8M eeeeeee eee eeeeee eeee eee MMe eee eeee eeeee, eeeee (MeMM8), eee eeeeeeeeeeee ee eeee e eeeeeee, eeeee eee eeeeeeee ee eeeee eeeeeeeeeeeeee (eeeeee eee, MMMe8) ee eeee eee eeeeeee ee ee eeeee eee; eeeee: 88.8 e (88%).

eee-88e-Meeeee-8,8e,8,8,8,88,88e,88-eeeeeeeee-8M-eeeee[e]eeeeeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

eee-8e-Meeeeeeeeeeeeeeeeeeeeeeee-8(8M)-eee eeeeeeeeeeeeeee (8 e, 88.8 eeee) eee eeeee MeMe8 (88 e, 888 eeee) eeee eeeeee ee eeeeeeeee eee MeMM eee 8 e. M8M eee eeeee ee eee eeeeee eeeeeee eee eeee eeeeeeeeee ee MeMM eee eeeee ee eeeeeeee eee Me(MM)8. Mee eeeeeee eee eeeeeeeee eeee Me8M eee eee eeeeeeee eeee eeeeee eeeeeeeeeeee eeee eee MMe eee ee MeMMM8, eeeee (Me8MM8), eee eeeeeeeeeeee, eee eeeeeeeee eeeeeeee eeeee eeeeeeee ee eeeeeee-eeeeeeee eeeeeeeeeeee (ee 888–888°M/8 Meee) eeeeee ‌88‌; eeeee: 8.88 e (88%); ee 88–88.8°M.

8-Meeeee-8,8,8,8-eeeeeeeeeeeeeeeeeeee[e]eeeeee (‌88‌); Meeeeee Meeeeeeee:[‌88‌]

M-Meeeeeeee-8-eeee-M′-eeeeee-M′-eeeeeeeeeeeeeeeeeeee (‌88‌; 8.88 e, 8 eeee) eee eeeeeeeee ee 8.8 M eeeeeeeeeeeeee eeee ee MeMM (888 eM). Meeee 8 e ee ee, eeeee M8MM8 eee eeeee eee eeee, eeeee 88 eee, eee eeeeeee eee eeeeeeee eee eee eeeeeeee eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeeeee eeee Me8M ee eeee ee eeee eeeeeeeee, eee eeee eeeeeeee eee eeeeeeeeeeee ee eeee ‌88‌; eeeee: 8.88 e (88%).

8-Meeee-8,8,8,8-eeeeeeeeee-8M-eeeeee[8,8-e]eeeee-8-eee (‌88‌, 8-Meeee-8,8,8,8-eeeeeeeeee-8M-β-eeeeeeee-8-eee); Meeeeee Meeeeeeee:[‌888‌]

8-(8-Meeeeeeeeeeeeeeeeeee)eeeeeeeee-8-eee (888 ee, 8.8 eeee) eee eeeeeeeee ee 88% MMM8M (8 eM) eee eee eeee eee eeeeee ee eee Meeeee eee ee e Meee eeeeeeeee eeee, eeeee eee eeeeee ee eeee eeeee (888 M) ee e eeeeeeeee eeee eee 8 eee. Mee eeeeeee eee eeeee ee M8M (8 eM) eee eee eeeeeeeeee eee eeeeee eee 8 eee, eee eeee eeeeee eee eeeeeeee ee eeee ‌88‌; eeeee: 8.888 e (88%); ee >888°M.

Meeeee 8-[8-(8-Meeeeeeeeeee)-8-(eeeeeeee-8-eeeeeeeee)-8M-eeeee-8-ee]-8,8-eeeeeeeeeeeeeeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

Me eeeeee 8,8-eeeeeeee-8-eeeeeeeeeeeee (8.88 e, 88.8 eeee) ee eeeeeee (888 eM) eeee 8-Å eeeeeeeee eeeeee (8 e) eee eeeee 8-(8-eeeeeeeeeeee)-8-[8-(eeeeeeee-8-eeeeeeeee)eeeeee]eeeeeeeee eeee, ee 8°M, MeMM (8.8 e, 88.8 eeee) eee eeeee. Meeee 8 e ee 8°M eee 88 e ee ee, eee eeeeee eeee eeeeeeee eee eee eee eeeeeeee eee eeeeeeeeeeee eeee eeeeeee eeeeeee eeee eeeee eeeee eee eeee eeeeeeeeee ee eeeeee eeeee eeeeee ee MeMM. Mee eeeeeee eee eeeeeeeee ee eeeeeeeee (88 e) eee eeee e eeeeeee ee M8M88 eee MeMM (8:88; 88 e) eee eeeee eee eee eeeeeee eee eeeeee, ee eee eeee, eee 8 e ee 88°M, eeee eee 8 e ee 88°M, eee eeeeeee eee 8 e ee 88°M. Mee eeeeeee eee eeeeee, eMeMMe (888 eM) eee eeeee, eeeeeeee ee 88.8% ee MeMM (888 eM) eeee 88 eee, eee eeee eee eeeee eee eeeeeee ee eM 88. Mee eeeeee eeee eeeeeeeee eee eee eeeeeee eeeee eee eeeeee eeee M8M, eeeeeeee eeeeeee eeeeee eee, eee eeeeeeeeeeee. Me eeeeeeee ee MeMM eee eeeeeee eeeeeeeeeeee ee eeee eee eeeeee ‌88‌; eeeee: 8.88 e (88%); ee 888–888°M.

8-Meeeee-8M-eeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

M eeee ee eeeeeeeeeeee eeeeeeeeeeeeeee (88 e) ee eee eeeeeee (888 eM) (MMMMMMM: eeeeeeeeee) eee eeeeee ee eeeeee eeeeee. MM8 eee eeeeee eeee eee eeee ee e eeee ee eeeee 8 eeeeeee eee eeeeee eee 8 e eee ee eeeee eeee eeee eeee eee ee eeeeeeeeee eeee. Mee eeeeeeeeeeee MM8•MM8 eee eeeeeeeee ee eeeeeeeeee eee eeeeee eeee eee eeeeeee (88 eM). Meeeeee ee eee eeeeeeee eeeee eeeeee eee eeeeeeeeeeeeeee ee 8-eeeeee-8M-eeeeee; eeeee: 88 e (88%). Meeeeeeeeeeeeeeee (MeMM) eeee eee eeeeeee; eeeee: 88 e (88.8%); ee 888–888°M.

M eeeeeee eeeeeeeee eee eeee eeeeeeee ee eeeeeeeee ee eee;[‌888‌] eeee eeee MeMe8 ee 888°M eeeeee eeee MM8; eeeee: 88%.

8-Meeeee-8-eeeeee-8M-eeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

MMMMMMM: Meeeeeeeeeeeeee ee e eeeeee eeee eeeeeeeeee, eee eee eeeeee eee eeeee eee eeeeeee.

MeMMMM8 (8.8 e, 88 eeee) eee 8-eeeeeeeeeeee-8-eee (8.8 e, 88 eeee) eeee eeeeee eeeeeeee ee eeeeeee (88 eM) eeee eeeeeeeeee eeeeeee ee M8M eee 8 e. Mee eeeeeee eee eeeeeeeeee eee eee eeeeeeee eeeee eeeeeeeee eee eeee eeeeee ee eeeeeeee eeeeee (88 eM) eee 88 e. Mee eeeeeee eee eeeeee, M8M (888 eM) eee eeeee, eee eee eeeee eee eeeeeeeee eeee Me8M. Mee eeeeeee eee eeeeee eeee eee MMe eee eeee M8M, eeee eeeee eee eeeeeeeeeeee ee eeee eee eeeeeee; eeeee: 8.8 e (88%); ee 88–88°M (eeeeeeeee eeeee).

8-Meeeee-8,8-eeeeeeee-8M-eeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

Me 8,8-eeeeeeeeeeeeeeee 8-eeeeeeeeeeeeee (8 e, 88 eeee) ee eee MM8Me8 (888 eM) eee eeeee MMe8 (8.8 eM, 88 eee). Meeee 88 eee ee ee, eee eeeeeee eee eeeeeeeeeee ee eee eeeeeeee ee eee. ee MeMMM8. Mee eeeeeee eeeee eee eeeeee eeee M8M, eeeee (Me8MM8), eee eeeeeeeeeeee. Mee eeeeeee eee eeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, eeeeeeeee eeeee/Me8M 8:8) eee eeeeeeeeeeeeeee (eeeeee) eeee eee eeeeeee; eeeee: 8.88 e (88%); ee 888–888°M.

8-Meeeee-8-eeeee-8M-eeeeee (‌88‌) eee 8-Meeeee-8-eeeee-8M-eeeeee (‌88‌):[‌88‌]

Meeeeeee (8-eeeeeeeeeee)eeeeeeeee (88.8 e, 888 eeee) ee eeeeeee (8888 eM) eee eeeee ee 88% M8MM8 (888 eM) eee eee eee-eeeee eeeeeee eee eeeeeee ee 888°M eee 8 e. Mee eeeeeee eeeee eee eeeeeeee eee, eeee eeee eeeeeee (888 eM) eee eeeee eee eee eeeeeee eee eeeeeeee eee eeeeeeeee eee e eeeeeee 8 e. Mee eeeeeee eeeee eee eeeeeeee eee eee eeeeeeee eeeeeee eeeee eeee eeeeeeeeeeee eeeeee eeeeeeee; eeeee: 88.8 e (88%); eeeee ee 8M MMM eeeeeeee ee eeeeeeee eee 8- eee 8-eeeeeeeeeee eeeeeee ee e eeeee ee 88:88. Mee eeeeeee eee eeeeeeeee ee 88% ee MeMM (888 eM) ee 88°M, eeee eee eeee eee eeee ee -8°M eee 88 e eeeee eeeee eee eeeeee eeee 8-eeeee eeeeee (8.8 e) eee eeeeeeeee ee eeeeeeeeee. Meeeeeee ee M8M (888 eM) ee eee eeeeeeee eeeeeeee e eeeeeee eeee (8.88 e), eee eeeeeeeeee e eeeeee eeeeeeeeee ee eee 8-eeeee eeeeee. Mee eee eeeee eeee eeeeeeee eee eeeeeeeeeeeeee (88% ee MeMM) ee eeee eeee 8-eeeeee-8-eeeee-8M-eeeeee (8.8 e); ee 888°M. Meeeeeeeeeeee ee eee eeeeee eeeeeee eeee e eeeee eeeee ee ee e 8:8 eeeeeee ee 8- eee 8-eeeee eeeeeee, eeeeeeeeeeeeeeeee (eeeeeee) ee e eeeeee (8.8 e) ee eeee eeeeeeee eeee 8-eeeeee-8-eeeee-8M-eeeeee (8.88 e) ee 88% eeeeee; eee eeeeeee eeeeeeeeeeeeeeeeee eeeeeeee eeee 8-eeeeee-8-eeeee-8M-eeeeee; ee 888°M.

8,8-Meeeeeee-8-(8-eeeeeeeeeee)-8M-eeeeee (‌88‌); Meeeeee Meeeeeeee:[‌888‌]

Me e eeee ee 8,8,8,8-eeeeeeeeeeeeeeeeeeeee (888 μM, 8.8 eeee) ee eeeeeee (8 eM) ee 8°M, eee eeeee eeeeeeee eeeee eeeee 8.8 M MeMe ee eeeeee (8.88 eM, 8.8 eeee). Mee eeee eee eeeeeee eee 88 eee ee 8°M eeee 8 M Me8MeMe ee eeeeee (8.8 eM, 8.8 eeee) eee eeeee. Mee eeeeeee eeee eeeeeeee eeeeee eeeeeeee eee 88 eee ee 8°M eee eee eeeeeeeee eeeeeeeeee eee eeeeeeee eeeeeee eeeeeee eeeeeeeee.

Me eee eeeeeeeeeeeeeee eeeeeeeeeeeeeeeeeeeee eeee (8.8 eeee) ee 8°M eee eeeee eeeee eeeee 8-eeeeeeeeeeee-8-eee (M)-eeeeee(eeeeee)eeeeeeeee (88 ee, 8.8 eeee). Meeee 8.8 e eeeeeeee ee 8°M eee 8.8 e ee ee, eee eeeeeee eee eeeeeee eeee eeeeee (8 eM) eee eeeeeeee ee eeeeeeeeee eeeeeeeeee eeee MeM (8.88 e, 8 eeee) eee M8M (8.8 eM). Mee eeeeeeeee eeeeeeeeee eee eeeeeeeeee eeeeeee eee 88 eee ee ee eee eeee eeeeeeee, eee eee eeeeeeeeeee eee eeeeee eeeeeee eeee eeeeee. Meeeeeeeeeeee eee eeeeeeeeeeee ee eeeeeeeeeeeeee (eeeeee eee, Me8M/eeeeee 8:88) eeee eee eeeeeee ee ee eee; eeeee: 88 ee (88%).

References