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Please login to access the full content or check if you have access via10.13.1.1.1.3.1.9.2 Variation 2: With Concomitant Introduction of a 3-Substituent
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Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 63.
Conducting the Larock synthesis in the presence of an aryl halide allows the trapping of the intermediate organopalladium intermediate and thus the linking of that aromatic moiety to the forming indole 3-position to give 225 (Scheme 79).[256]
Meeeee 88 Meeeee Meeeeeeee eeee Meeeeeeeeee Meeeeeeeeeee ee e 8-Meee Meeeeeeeeee[888]
| M8 | M8 | M8 | Me8 | Meeee (%) | Mee |
|---|---|---|---|---|---|
| M | M | Me | Me | 88 | [888] |
| M | M | Me | 8-MeM8MM8M8 | 88 | [888] |
| MM8Me | M | 8-Mee | Me | 88 | [888] |
| M | MM | M | Me | 88 | [888] |
Meeeeeeeeeee Meeeeeeee
8,8-Meeeeeee-8M-eeeeee (888, M8 = M8 = M; M8 = Me8 = Me); Meeeeee Meeeeeeee:[888]
Me e 88-eM, eeeee-eeeeee eeeee, eeeeeeee eeee e eeeeeeee eeeeeee eee, e eeeeeeeeeeee, eee ee eeeee eeeee, eeee eeeeeee 8,8,8-eeeeeeeee-M-(8-eeeeeeeeee)eeeeeeeee (8.8 e, 8.88 eeee, 8.8 eeeee), Me(MMe)8 (88 ee, 8.88 eeee, 8.88 eeeee), Me8M (88 ee, 8.888 eeee, 8.8 eeeee), eee M8MM8 (8.88 e, 8.88 eeee, 8 eeeee), eeeeeeee ee eeeeeeee ee eeeee MMM (8 eM). Meee eeeeeeee ee ee, eeee eeeee eeeeeeeeeeeeeee (8.88 eeee, 8.8 eeeee) eee eeeeeeeeeeee (8.88 eeee, 8.8 eeeee). Mee eeeeeee eee eeee eeeeee ee 88°M eeeee eee eeeeeeee eee eeeeeeee. Mee eeeeeee eee eeeeeeee eeee M8M, eee eee eeeeeee eeee eee eeeeeeeee eeee MeMMe (8 ×). Mee eeeeeee eeee eee eeeeee eeee eee eeeee eee eeeee (Me8MM8) eee eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee ee eeee eee eeeeee ee ee eee-eeeee eeeee; eeeee: 88%; ee 888–888°M.
References
| [256] | Me, M. M.; Meee, M.; Mee, M.-M.; Meeeee, M.; Meeeee, M.; Meeeeeeeee, M. M., Mee. Meee., (8888) 8, 8888. |
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