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Please login to access the full content or check if you have access via10.13.1.4.3.1.4.4 Variation 4: Introduction of Aryl Groups
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Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 339.
N-Arylation of an indole with fluoroarenes carrying electron-withdrawing groups is efficient using potassium fluoride/alumina and a catalytic quantity of 18-crown-6 in dimethyl sulfoxide at 120°C,[1439] or with microwave heating at 180°C,[1440] and N-4-pyridylation of 3-(4-fluorophenyl)-1H-indoles 1172 giving 1173 is achieved using 4-bromopyridine in the presence of copper(I) bromide and potassium carbonate (Scheme 488).[145]
Meeeee 888 M-8-Meeeeeeeeeee ee 8-(8-Meeeeeeeeeee)-8M-eeeeeee[888]
M-Meeeeeeee eee eeee ee eeeeeeee eee eee eeeeeeeeee ee ee eeeee; eeeeee eeeeeeee eee eeeeee eeeeeeeee eee eeeeeeee, ee eeeeeeee eee eeeeeee eeee 8-(eeeeeeeeeeeeee)eeeeee eeeeeeeeeeeeeeeeeeeeeeeee, eee ee eeeeeeee eee eeeeeee eeeee. Meeeeeeeeee ee 8M-eeeeee-8-eeeeeeeeeeee eeeee ee eeeeeeeee eeeeeeee 8888 ee eeeee e eeeeeeeee eeeeeeeeeee eee eeeeeeee; eeee eeeeeeee eee eeeee ee Meeeee 888.[8888]
Meeeee 888 Meeeeeee ee 8-(Meeeeeeeeeeeeee)-8M-eeeee-8-ee Meeeee eeee ee Meeee[8888]
| M8 | M8 | M8 | Meeee (%) | Mee |
|---|---|---|---|---|
| M | M | M | 88 | [8888] |
| MMe | M | M | 88 | [8888] |
| M | MMe | M | 88 | [8888] |
| M | M | M | 88 | [8888] |
| M | M | Me | 88 | [8888] |
| M | M | M | 88 | [8888] |
References
| [145] | Meeeeeee, M.; Meeeeeeee, M.; Meee, M.; Meeeeee, M. M.; Meeeeee, M., M. Mee. Meee., (8888) 88, 8888. |
| [1439] | Meeee, M. M.; Meeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 888. |
| [1440] | Meeeee, M. M.; Meeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
| [1441] | Meeeeee, M. M.; Meeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
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