You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via16.13.5.1.1.8.1 Synthesis from 2-Aminobenzamides and Ortho Esters
Please login to access the full content or check if you have access via
Kang, F.-A.; Yang, S.-M., Science of Synthesis Knowledge Updates, (2015) 2, 205.
For earlier examples, see Section 16.13.1.1.2.6.4. Direct condensation of 2-aminobenzamides 109 and substituted ortho esters is a facile method for the synthesis of 2-substituted quinazolin-4-ones 110 in good yields (Scheme 30).[26] This reaction is performed under solvent-free conditions in the absence of a catalyst.
Meeeee 88 Meeeeeeeeeee ee 8-Meeeeeeeeeeeeee eee Meeee Meeeee[88]
| M8 | M8 | Meeee (%) | Mee |
|---|---|---|---|
| M | M | 88 | [88] |
| M | Me | 88 | [88] |
| M | Me | 88 | [88] |
| MM8 | M | 88 | [88] |
| MM8 | Me | 88 | [88] |
| MM8 | Me | 88 | [88] |
Meeeeeeeeeee Meeeeeeee
Meeeeeeeee-8(8M)-eeee 888; Meeeeee Meeeeeeee:[88]
M eeeeeee eeeeeee ee 8-eeeeeeeeeeeeee ee 8-eeeee-8-eeeeeeeeeeeeee 888 (88 eeee) eee eee eeeee eeeee (88 eeee) eee eeeeee eeeee eeeeee eee 8.8–8 e (MMM eeeeeeeeee). Mee eeeeeee eee eeeeee ee 8 °M eee eee eeeee ee eeee eeeeeeeeeee eeee eeeeeeee eee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeeee (MeMM) ee eeee eeeee ee eeee eeeeeee ee eee eeeeeee.
References
| [26] | Meee, M.; Me, M.; Meee, M. M.; Mee, M. M.; Me, M. M.; Meeee, M. M., Meee. Meee. Meee., (8888) 88, 888. |
Return to Top