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DOI: 10.1055/sos-SD-118-00076

Kubik, S.Science of Synthesis Knowledge Updates, (20133272.

The Read synthesis of hydantoins is a two-step process wherein an α-amino acid is treated with potassium cyanate with subsequent heating of the product in concentrated aqueous hydrochloric acid to produce the hydantoin (Scheme 86). Thus, hydantoins with a single substituent at the 5-position are accessible or, if N-substituted α-amino acids are used, hydantoins that have substituents at the 1- and 5-positions are obtainable.[‌236‌]

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