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DOI:
10.1055/sos-SD-120-00326
Rawat, V. K.; Mita, T., Science of Synthesis Knowledge Updates, early view.
The carboxylation of alkyl (pseudo)halides with carbon dioxide typically involves the use of transition-metal catalysts, which undergo oxidative addition with the alkyl (pseudo)halide substrates. The generated reactive alkylmetal intermediates promote subsequent carboxylation with carbon dioxide. Over the years, many transition-metal catalysts have been explored for this transformation and have been found to confer unique reactivity to afford a variety of alkanoic acid derivatives.
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