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DOI: 10.1055/sos-SD-122-00001

Li, X.; Song, Q.Science of Synthesis Knowledge Updates, (20241309.

To date, the most direct and reliable method to access thioacyl chlorides is still the halogenation of thiocarboxylic acids. For example, in work reported by the Sekar group, chlorination reagents such as oxalyl chloride or thionyl chloride were employed in reactions with thiocarboxylic acids to afford the corresponding thioacyl chlorides 1 as crude products; these were subsequently treated with alkoxyamine hydrochloride salts to give the target N-alkoxy thioamides 2 (Scheme 1).[‌2‌]

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