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DOI: 10.1055/sos-SD-126-00085

Sellars, J. D.Science of Synthesis Knowledge Updates, (20141398.

Whilst traditionally undertaken with aluminum trichloride and an acid chloride,[‌3‌] recent studies have demonstrated that the use of aluminum metal with microwave heating allows arenes and acid chlorides to react smoothly to produce aryl ketones.[‌4‌] Alternatively, in situ generation of an aluminum(III) species using electrochemical methods has permitted a two-step reaction to produce aryl ketones in good yield (Scheme 2).[‌5‌]

Meeeee 8 Meeeeeeee Meeee Meeeeeeeeee Meeeeee ee Meeeeeee[‌8‌,‌8‌]

Meeeeeeeeee 8

Me8 Meeeeeeeee Meeee (%) Mee
Me Me eeeee eeeeee (eeeeeeee), eeeeeeeee (888 M) 88 [‌8‌]
Me Me eeeee, MM8Me8, ee, 8–8 eM·ee−8 88 [‌8‌]
8-Mee Me eeeee eeeeee (eeeeeeee), eeeeeeeee (888 M) 88 [‌8‌]
8-Mee Me eeeee, MM8Me8, ee, 8–8 eM·ee−8 88 [‌8‌]
8-MeMM8M8 Me eeeee eeeeee (eeeeeeee), eeeeeeeee (888 M) 88 [‌8‌]
8-MeMM8M8 Me eeeee, MM8Me8, ee, 8–8 eM·ee−8 88 [‌8‌]

Meeeeeeeeeeeeee eeeee eeeeee eeeeeee, eeeee eeeee eeeee eee eeee eeeeeeee eeee eeeeeeeeeeee eeeeeeeee ee eeee eeeeeeeeeeeeee. Meeee 88 eeeeee eeee ee eeeeee, eeeeeee, eee eeeeeeee eeee eeeeeeee eeeeeeeee eeeee ee eeeee eeeeeeeee eee/ee eee eeeeeeee. M eeeeeeeee eeeeee ee eee eeeeeeeeeeeee eeeee eeeeeeeeeeeeeeeeeeeeeeeee (8 eee%) eeeeee eee eeeeee Meeeeee–Meeeee eeeeeeeee ee e eeeeeee ee eeeeee eeee eeeee eeeeeeeee eeeee eeeeeeeee eeeeeeeeeee (Meeeee 8).[‌8‌]

Meeeee 8 Meeeeeeee Meeee Meeeeee(MMM), Meeeee(MMM), eee Meeeeeee(MMM) Meeeeeeeeeeeeeeeeeeeeeeeee[‌8‌]

Meeeeeeeeee 8

M8 M8 Meeeeeee Meeeeeeeeee Meee (eee) Meeee (%) Mee
Me Me Me(MMe)8 8 88 [‌8‌]
M MMe Me(MMe)8 8 88 [‌8‌]
Me Me Me(MMe)8 88 88 [‌8‌]
M MMe Me(MMe)8 8 88 [‌8‌]
Me Me Me(MMe)8 88 88 [‌8‌]
M MMe Me(MMe)8 8 88 [‌8‌]

Me eeeeeeee, eeeeee eeeeeeeee eee Meeeeee–Meeeee eeeeeeee ee eeeeeeee-eeee eeeeee eeee eeeee eeeeeeeee ee e eeeeeeee eeeeeeeee ee eeeeeee eee ee eeee eeeeeeeeee ee eeeeee(MMM) eeeeeeee; eeeeeee, eeee eeeeee(MMM) eeeeeeee ee eeeeeeee, eee eeeeee ee eeeeeeee eee eeeeeeee, eeeeeeee eee eeeeeeee eee eeeeeee ee ee eeeee eeeeeee eeeeeeeee ee eeeeee eeeeeee eeeeeeeeee eeeeeeeeeeeeeeee eee eeeeeeeee (Meeeee 8).[‌8‌] Meeeeeeeeeee, eeeee 88 eeeee eeeeeeeee eeee eeee eeeeeeee ee Meeeeee–Meeeee eeeeeeeee.[‌8‌] Mee eeeeeeeee ee eeeeeeeeeee eeeee [88 eee% eeeeeee(MMM) eeeeeeee eee 88 eee% eeeeee(M) eeeeeeeeeee] eeeeeeeee eee eeeeeeee ee eeeeeeee-eeee eeeeee eeee eeeee eee eeee eeeeeeeeee ee eeee eee eeeeeeeeeeeee eeee eeeeeee. Mee eeeeeeeeeee eeeee eee eeeeeeee ee eeeeeeee eee eeeeee eeeeeeee eee eeeeeeeee eee eeeeeee eee.[‌8‌‌88‌] Meeeeee eeeeee eee eeee-ee-eeeeee eeeeeeee eeee eeeeeeee ee eeeeeeeee ee eeeeeee(MMM) eeeeeeeeeeeeeeeeeeeeeeeee eeeee, ee eee eeeeeeee ee eeee eeeeeeeeee ee eee eeeee eeeeee 8-eeeee-8-eeeeeeeeeeeeeeeee eeeeeeeeeeeeeeeeeee ([eeee]MM8), eeeeeeee eee eeeeeeee ee eeeeeeeee eeeeee ee eeeeeee eeee eeeeee ee eeee eeeeeee ee eee eeeeeeee eeeeeeee (88 ee 8 eee%, eeeeeeeeeeee).[‌88‌,‌88‌]

Meeeee 8 Meeeee-Meeee-Meeeeeee Meeeeee–Meeeee Meeeeeee[‌8‌]

Meeeeeeeeee 8

Me8 Meee (e) Meeee (%) Mee
8-Me8MM8M8 8.88 88 [‌8‌]
8-MeMM8M8 8 88 [‌8‌]
8,8,8-(MeM)8M8M8 8.8 88 [‌8‌]