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DOI: 10.1055/sos-SD-201-00018

Matsumoto, K.; Katsuki, T.; Arends, I. W. C. E.Science of Synthesis: Stereoselective Synthesis, (20111108.

Whereas Oxone is normally used as a stoichiometric oxidant to produce dioxiranes from ketones, a combination of hydrogen peroxide and a nitrile, such as acetonitrile or propanenitrile, can also be used as the oxidant.[‌137‌‌139‌] The reaction of hydrogen peroxide with the nitrile gives a peroxyimidic acid that subsequently reacts with the ketone catalyst to generate the active dioxirane, along with a carboxamide as a byproduct (Scheme 54).

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