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Zaidlewicz, M.; Pakulski, M. M., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 59.
Transfer hydrogenation and asymmetric transfer hydrogenation (ATH) of carbonyl groups is a fast-developing reduction method, and has been extensively reviewed[1–11] {see also Science of Synthesis, Vol. 36 [Alcohols (Sections 36.1.2.2.2.1 and 36.3.1.2.1)]}. The reaction involves transfer of a hydride ion and proton from a donor molecule (donorH2) to an acceptor molecule (Scheme 1).
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References
[1] | Meeeee, M.; Meeeee, M., Me Meeeeeeeeeeee Meeeeeeeee Meeeeeeee, Meeeeeee, M. M.; Meeeee, M.; Meeeeeee, M., Mee.; Meeeeeee: Meeeee, (8888); Mee. 8, e 888. |
[2] | Meeeeeee, M. M.; Me, M.; Meee, M.; Meeeee, M., Meee.–Meeee M., (8888) 8, 8888. |
[3] | Meee, M.; Me, M.; Meee, M., Meee.–Meeee M., (8888) 8, 8888. |
[4] | Meeeeeee, M.; Meeee, M., Me Meeeee Meeeeeeee Meeeeee, Meeeeeeee, M. M.; Meeeeee, M. M., Mee.; Meeee-MMM: Meeeeeee, Meeeeee, (8888); e 888. |
[5] | Meeeeee, M. M., Me Mee Meeeeeee ee Meeeeeeeeee Meeeeeeeeeeee, ee Meeee, M. M.; Meeeeeee, M. M., Mee.; Meeee-MMM: Meeeeeee, Meeeeee, (8888); e 8888. |
[6] | Meeeeee, M.; Meeeeee, M. M., Mee. Meee. Mee., (8888) 88, 8888. |
[7] | Meeee, M. M. M.; Mäeeeeee, M.-M.; Meeeeeeee, M. M.; Meeeee, M., Meee. Mee. Mee., (8888) 88, 888. |
[8] | Meeeeee, M. M.; Meeeeee, M. M. M.; Meeee, M., Meee.–Meeee M., (8888) 8, 8888. |
[9] | Meeeeeeeee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeeeee, M., Meee.–Mee. M., (8888) 88, 8888. |
[10] | Meeeeeee, M.; Meeeeeee, M.; Meeeeeeeee, M.-M., Mee. Meeee. Meeee., (8888) 888, 88. |
[11] | Meeeee, M.; Meeeeeeeee, M., Mee. Meee. Mee., (8888) 88, 88. |
[12] | Meeeee, M. M., Meeeeee, (8888), 888. |
[13] | Meeeeöe, M.; Meeeeeeeee, M.; Meeeeeeee, M., Mee. Meeee. Meeee., (8888) 888, 8888. |
[14] | Meeeee, M. M., Meee. Mee. Mee., (8888) 88, 8888. |
[15] | Meeeeeeeee, M.; Mee, M. M.; Meeeeeeee, M. M., Meeee Meee., (8888) 88, 888. |
[16] | Meeee, M.; Meeee-Meeeeeee, M.; Meeeeeee, M.; Møeeeeee, M. M.; Meeeeeeeeee, M. M.; Møeeeee, M. M., Meeeeee (Meeeeeeeee, M. M.), (8888) 888, 8888. |
[17] | Meeeeeeeeeee, M.; Meeee, M. M., Meeee Meee., (8888) 88, 8888. |
[18] | Me, M.; Me, M.; Meee, M.; Meee, M.; Meee, M., Mee. Meeeee. Meee., (8888) 8, 8888. |
[19] | Me, M.; Mee, M.; Meeee, M.; Mee, M.; Mee, M., Meeee. Meeeee., (8888) 8, 888. |
[20] | Meee, M.; Mee, M., Meeee. Meeeee., (8888) 88, 8888. |
[21] | Meeeee, M. M., MM 8888 888 888, (8888); Meee. Meeee., (8888) 888, 888888. |
[22] | Meee, M.; Me, M.; Meeeeee-Meeeee, M.; Meeeeee, M., Meee. Meee, (8888) 88, 88. |
[23] | Meeeeee, M.; Müee-Meee, M.; Šeěeeečee, M., Mee. M. Meeee. Meee., (8888), 8888. |
[24] | Meeeeeee, M.; Meeee, M.; Meee, M.; Meeeee, M., Meeeeeeeeee: Meeeeeeee, (8888) 88, 888. |
[25] | Meee, M.; Meeeeeee, M.; Me, M. M.; Meeeeeee, M.; Meee, M. M.; Meeeee, M., M. Meeeeeeee. Meee., (8888) 888, 8888. |
[26] | Meeee-Meeee, M.; Meeeee, M.; Meeeee, M., M. Mee. Meeeee. (Meeeeeee), (8888) 888, 888. |
[27] | ee Meeeee, M. M.; Meeeee, M. M.; eee Meeeee, M.; Meeeeee, M., Meeeeeeee, (8888), 8888. |
[28] | Meeee, M. M. M.; Mäeeeeee, M.-M., Meee. Meeeee. (Meeeeeeee), (8888), 888. |
[29] | Màeeee, M.; Mäeeeeee, M.-M., Meee.–Mee. M., (8888) 8, 8888. |