Science of Synthesis

MacMillan, D. W. C.; Watson, A. J. B., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 312.

Enantioselective cycloaddition reactions are a powerful method for the rapid construction of densely functionalized ring systems from relatively simple substrates. Specifically, the catalytic enantioselective Diels–Alder reaction has found extensive utility within complex molecule synthesis.[‌29‌–‌31‌] Consequently, this particular reaction has become a benchmark for the evaluation of new concepts within asymmetric catalysis.

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References