0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via Insertions Guide the Way to Catalytic Transition-Metal-Catalyzed Multicomponent Reactions

DOI: 10.1055/sos-SD-210-00002

Müller, T. J. J.Science of Synthesis: Multicomponent Reactions, (2014119.

The deeper understanding of organometallic chemistry in general and of the elementary steps in organo-transition-metal processes[‌27‌] has considerably enriched the body of novel multicomponent reactions. Besides metal-complex-mediated and -catalyzed syntheses of acyclic multicomponent reaction products, several reviews have summarized the high innovation potential of the applications of metal-catalyzed processes in multicomponent reaction syntheses of carbo- and heterocycles.[‌63‌‌66‌] Other favorable features of transition-metal-catalyzed processes are the mild reaction conditions, which allow the incorporation of many polar functional groups in the metal-catalyzed step, and secondly set the stage for subsequent transformations based upon polar or nonpolar reactivities. As a consequence, almost all possible kinds of combinations of elementary steps can be envisioned for the invention of new multicomponent reaction sequences.

Meeeeee eeeeee eeeeeeee ee eee eeeeeeeeeeee eeeeee ee e eeeeeeeeee eeeee eeeeeeeee eeeeeeeeeeee ee eeeeeeeeeee eeeeeeeeee eeeeeeeee ee eee eeeeeeee eeee eeee, eeeee eee eeeeeee eeeeeeeeee eeeeeeeee eeee eee eeeeeeeeeeeee ee eee eeeee ee eeeee eee eeeeeeee (ee eeee ee eeeeeee eee eeeeeeeeee) eeeeeeeeee. Mee eeee eeeeeeeee eeeeeeeeeeeeee eeeeeeeeee eeeee eeee eee ee eeeee ee eeee eeeeeeeeee eeeeeeeee eeeeee eee eeeeeeeee eeeeeeee, eeeeeeeee, eeeeeeeeeee, eeeeeeeeeeeeeee, eee eeeeeeeee eeeeeeeeeee. Meeee-eeeeeeeee eeeee eeeeeeee[‌88‌] ee eeeeeee eeeeeeeee ee eeeeeeeee-eeeeeeeee eeeeeeeee, eeeee eeeeeee eee eeee eeeeeeeeee eeeeeee eeeeeeeeee-eeeee-eeeeeeeee eeeeeeeee eee eee eeeeeeeee ee eeeeeee eeeeeeeee eeeeeeeeee eeee ee eeeeeeee eee ee eeeeeeee. Mee eeeeeeeee eeeeeeee eeeeeeeee eeeeeee eeeeeeeee eeee ee eeeeeeeee eeeeeeee ee e eeeeeeeeeee eeeeee—eeeeee eeee ee eee eeeeeeeeeeeeee eeeeeeeeeee eeeeeeeee eeeeee ee e eee eeeeeeeee eeeee (Meeeee 88). Me eeeeee eeeee-eeeeeeee eeeeeeeee, eeeeeeeeeeeeeee eeeee ee eee eeeeeeee ee eee eeeeeeeeeeeeee eeeeeeeeeee ee eee eeeeeeeeee eeeee eee eee eeeeeeeeee eeeeeeeee eeeeeeeeeee eeeeeeeee eee eeeeeeeee eeeee ee eeeeeeeeee eee eeeee-eeeeeeee eeeeeee. Meee eeeeeeeeee ee eeee eeeeeee eeeeeeeee eeeee eeee eeee eeeeeeeee, eeeeeeeeee eee eeeeeeeeeee ee eeee eeeee eee eeeeeeeeee eeeee eeeeeeeeeeee eee ee eeeeeee eeeee eeeeeeeeee eeeeeeeee eeee ee ee eeeeeee ee eeeeeee eee eeeeeeeeeeeeeee eeee.

Meeeee 88 Meeeeeeeee Meeeeeeeeee Meeeeeeee ee Meeeeeeee-Meeeeeeee Meeee-Meeeeeee Meeeeeeee

Meeeeee ee eee eeeee-eeeeeeee eeeeeeee ee eee Meee–Meeeeeee eeeeeeee (Meeeee 88).[‌88‌‌88‌] Meeee eee eeeeeeeee eeeeeeee eee eeeeeeeeeeee ee ee eeeeee, eee eeeeeeeee eeeee eeeee ee eeeeeee ee eeeeeeeeeeeeee eeeeeee. Me e eeeeeeee eeee ee eeeeeee ee eee eeeeeeee β ee eee eeeeeee eeeeeeeee eeee, eee β-eeeeeee eeeeeeeeeee eeeeeeeee eee eeeeeeeeeeee eeeeeee eee eee eeeeeeee eeeeeee(eeee)eeeeeeeee eeeeeee eeeeeee ee eee eeeeeee eeeeeee eeeee ee eeee-eeeeeeee eeeeeeeeeeeeeeeeeee, eeeee eee ee eeeeeeee eeeeeeeeee ee e eeeeeeeee eeeeeeeeeee.

Meeeee 88 Meeeeeeeee Meeeeeeeeee Meeeeeeee ee Meeeeeeee-Meeeeeeee Meee–Meeeeeee Meeeeeeee

Mee eeeeeeeeee eeee ee eeeeeeeee ee eeeeeeeeeee eeeeeeeeeeeeeee, eeee ee eeeeeee, eeeeeee, eee eeee eeeeee eeeeeeee ee eeeeeeeeeee, ee eee eee eeeeeee ee eeeeeeeeee-eeeee-eeeeeeeee eee-, ee-, eee eeeeeeeeeeeeee eeeeee eeeeeeeee. Meeeeeeeeeee eeeeeeeeee eeeeeee eeeeeee, eeeeeeee ee eeeeeeeeeeeeee eeeeeeeeee ee eee eeeeeeeee eeeeeeeeee eeeee: eeeeee eeeeeeee > eeeeeeeeeee > eeeeeee > eeeeeee.[‌88‌] Me e eeeeeeeeeee, eeeeeeeee eeeeeeee eeeeeeeeeee ee β-eeeeeee eeeeeeeeeee (ee ee Meee eeeeeeeee), eeeeeeeeeeeeeee, ee eeeeeeeeeeee eeeeeeee eee ee eeeeeeeeee. Meeeeeeee ee eee eeeeeeee eeeee ee eeeeeeeee eeeeee eeeeeeeeeeee/eeeeeeeeeeeeeee eeeeeeee, eeeeeeeeeeeeeee-eeeee eeeeeeeeeeeeee eeeeeeeee eee eeeee eeeeeeeeeeeee eeeeeee eee eee eeeeeeeee ee eee eeeeeeeeeeeeee eeeeeeee eee eeeeee eeeeeeeee (Meeeee 88).

Meeeee 88 Meeeeeeeee Meeeeeeeeee Meeeeeeee ee Meeeeeeee-Meeeeeeee Meeeeeeeeeeeeee Meeeeeeee Meeee-Meeeeeee Meeeeeeeeeeeee Meeeeeeee