Science of Synthesis

Müller, T. J. J., Science of Synthesis: Multicomponent Reactions, (2014) 1, 23.

Multicomponent reactions are often associated with diversity-oriented synthesis. This concept, introduced by Schreiber,[‌82‌,‌83‌] points out the structural dimension accessible by a specific reaction or sequence of reactions. The ultimate goal is definitely accessing the utmost flexibility with as many functional variations as possible and with as few synthetic strategies as necessary. Ideally, each step involved should generate structural complexity. This approach is particularly advantageous for lead development in pharmaceutical chemistry and agrochemistry,[‌19‌–‌22‌,‌84‌] but also increasingly important with respect to functional π-systems[‌24‌,‌25‌] in future molecular photonics, electronics, and magnetics.

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‌Meeeee 88‌ Meeeeeee-Meeee (Meeeeeeee) Meeeeeeee (Meeeeeeee ee M8, M8, M8, eee M8)

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‌Meeeee 88‌ Meeeeeeeeeeeee Meeeeeeee (Meeeeeeee ee M8, M8, M8, eee M8 eee Meeeeeeeeee Meeeeeeeee)

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‌Meeeee 88‌ Meeeeeee Meeeeeeee (Meeeeeeee ee M8, M8, M8, eee M8 eee Meeeeeeeeeeeee Meeeeeee ee Meeeeeeeeeeeee Meeeeeee Meeeeeeeee)

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‌Meeeee 88‌ Mee Meeee Meeeeeeeeeeee ee e Meeee ee Meeeeeeee ee Meeeeeeeeeeeee Meeeeeeee

Me eeeeeeeee, eeee eeeeeeee eeeeeeeeeeeee eeee eee ee eeeeeee eeeeeee e eeeeeeeeeeeeee eeeeeeee eeeeeeeee eeeeeeeeee e eee eeeee ee eeeeeeeee. Meee eeeeeee ee e eeeeeeee eeeeeeeee ee eeeeeeeeee eee eeeeeeeeeeeeee eeeeeeeee ee eeeeeeeee eeeeeeeeeee eeeeeeeeeeeeee eeeeeeeee ee eeeee eeeeeeeee.[‌88‌–‌88‌] Meeeeeeeeee, e eeeeeeeeee-eeeee eeeeeee ee eeeeeeeeeeeeee eeeeeeeee eeeeeeeeee eeeee ee eee eeeeeeee ee eee eeeeeeeee ee e eee-eee eeeeeee. Meeeeeee eeee e eeeeeeee eeeeeeeeee eee ee eeeee eeeeeeeeeeeee eee eeeeeeeeeeeeeee, eee eeeeeeeeeee ee eeeeeeeee eee eeeeeeeeeeeeee eeeeeeeee eeeee eeee eeee-eeeeeeeeeee, eee, eee eeeeee eeeeeeeee eeeee eeee eeeee eeeeeeee eee ee eee eeeeee ee eeee eee. Meeeeeeeee, eee eee ee eee eeeee.

References