Science of Synthesis

Ayaz, M.; De Moliner, F.; Morales, G. A.; Hulme, C., Science of Synthesis: Multicomponent Reactions, (2014) 1, 99.

General Introduction

The Strecker three-component reaction, which affords an α-aminonitrile on reaction of a carbonyl-containing compound, an amine, and a cyanide salt source, represents one of the earliest examples of a multicomponent reaction (‌Scheme 1‌). Since Adolph Strecker described in 1850 the first preparation of alanine via the simple mixing of acetaldehyde, ammonia, and hydrogen cyanide,[‌1‌] the robustness, simplicity, and atom economy of this reaction anticipated what years later would be recognized as key, common features of most multicomponent reactions.

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References