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DOI: 10.1055/sos-SD-210-00078

Bernardi, L.; Ricci, A.Science of Synthesis: Multicomponent Reactions, (20141123.

General Introduction

The one-pot formation of optically active β-amino carbonyl compounds (Mannich bases) from the reaction of an enolizable ketone with formaldehyde and an amine was first recognized by Mannich.[‌1‌] In practice, enolizable aldehydes or ketones serve as the CH-acidic substrate for direct Mannich reactions (Scheme 1). The Mannich reaction is one of the most useful reactions for the synthesis of nitrogen-containing compounds as well as an effective method for the construction of C—C bonds.[‌2‌]

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