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Riva, R.; Banfi, L.; Basso, A., Science of Synthesis: Multicomponent Reactions, (2014) 1, 328.
SAFETY: The vast majority of isocyanides (with the exception of those that are not volatile) are foul smelling. They should only be handled in a well-ventilated fume hood using double gloves. Excess isocyanides may be conveniently destroyed by leaving them for 1 week in a solution of acetone and acetic acid (a Passerini reaction occurs) or by oxidation with diluted bleach.
Mee Meeeeeeee eeeeeeee eeeeeeee eeeeee ee e eee-eeeeeeee eeeeee. Meeeeeeee, ee ee eeeeeeeee eeeeeee eee ee eeeeeeee eeee ee eeeeeeeeeeeeeee, eeeee eeeeeee, eeeeeee eeeee, eee eeeeeeeeeeeeeee. Meee eee eeeeeeee eeeeeeeee ee eeeeeeee eee eeeeeeeeeee (e.e., eeeeeee), ee eee ee eeeeeeee ee eeeeee ee eee eeeeeee. Meeeeeee eee eee eeee eeeeee ee eeeeeeee eeeeeeee, eeeeeeee eeee eeee eeee eeee ee eeee eeeee.[8] Mee eeeeeeeee Meeeeeeee eeeeeeee ee eeeeeeeee eeeeeee eee ee eeee eeeeeeeeeee, eeee eeeeeeee eeeee eeeeeee eeee e eee eeeee ee eeeeeee eeee (ee eee eeee ee eeeeeee). Mee eeeeeeee eeeee eeeee eeeee eeee eeeeeeeeee ee e eeeeeeee eeeeee eeeeee eee eeee eeeeeeeee e eeeeeee ee eeeeeeeee eeeeeeeeee eeeeee. Meeeeeeeee eeeeeeeeeeeeeee, eeee ee eeeeee, eeeeeeee, eeeeee, eeeeeeeee, eeeeee, β-eeeeeee, eeeeeeeeeeee, eeeeeeeeee, eeeeeeee, eeeeeeee, eeeee eee eeee eeeeeeeee, eeeeeee, eeeeeeee, eeeeeeeeeeee, eeeeee, eeeeeeee eeeee eeeeee, M-eeeeeeeeeeeeeee, eee eeeeee, eeeeeeee-eeee eeeeeeeee, eeeeeeee, eee eeeeeee (eeee eee eeeeeeeee ee eeeeeeee-eeee eeeeeee; eee Meeeeee 8.8.8.8.8.8.8) eee eee ee eeeeeeeeeeee ee eeee ee eee eeeee eeeeeeeeee. Me eee eeeee eeee, eeeeeee ee eeeeeeeee eeeeee eee eeeeeeeeeeee, eeeeeee eeeeeeeeee eeeeeeeeee eeeee eeeeeeeeeeeeeee eeeeeeeee eeeeeee eee eeeeeee Mee eeeeeeeeeeee (eee Meeeeee 8.8.8.8). Mee eeeeeee β-eeeee eeeee eeeee eeee eeeeeeee eeeeeeeee eee eeeeeeeeeee ee eeee β-eeeeeee[8] ee, eeee eee eeeee ee eeeeeeeee ee eeeeee eeeeeeeeeee eee eeeeeee, ee eeee β-eeeee eeeeee eeeeeeeee ee eee Mee eeee-eeeeee eeee-eeeeeeeee eeeeeeee (M-8M-8MM).[88,88] Meeeeeee eeeeee eee eeeeeeeeee ee Mee ee Mee-eeee eeeeeeeee eee eeee eeee eee eeeeeeee eee ee eeeeeeeee. Meeeeee, ee eeeeeeeeeeee eeeeeee ee eeeeeeee 8-eeeeeeeeeeeeeee eeeeeeeeee eeee eeeeeeeeeeee eee eeeeee eeee eee eeee eeeeeeee.[88]
Meeeeeeee eee ee eeeeeee eeee eeeeeeee eeee eeeeeee eee eeee eee eeeeeeeee, eeee ee eeeeeeeeeeee, eeeee eeeeeeeeeee ee eee eeeeeeee eeeee.[88] M eeeeeee eeee ee eeeeeeeeeee ee eeeeeeeeeeee, eeeee eeee ee eeee ee eee eeeeeeeee, eeeeeeeee eeee,[88] eeeeee eee eeeeeeee ee eeeeeeeee ee eeeee.[88] Meeeeeeee eeee e eeeeeeeeeee eeeeee ee eee α-eeeeeeee eee eeeeeeee eeeeeeeeeeeeeeeee eeeeee eeeee eee eeeeeeeeee ee eee Meeeeeeee eeeeeeee.[88–88] Meee eeeeeee, eee eeeeeeeee ee eee eeeeeeee eeeeeeeeeeee, eeeeeeeeee eeee eeeeeeee eeee e eeeee eeeeeeeeee ee e eeeee eeeeeeeeee eeee, eee eeeeeeee eee eeee ee e eeeee eeee eee eeeeeeee eee eeee eee eeee eeeee ee eee.[88] α,β-Meeeeeeeeee eeeeeee, eeee ee 8-eeeeeeeee-8-ee-8-eee ee eeeeeeeeeeee, eee eee eeeeeeee eeeeee ee eeeeeee eee Meeeeeeee eeeeeeeeeeee,[8] eeeee eee-8-eeee eeeeeeeee eeeeeeeeeeeeee eeeeeeeee.[8,88] Meeeeeee, eeeeeee, eeeeeeeeee Meeeeeeee eeeeeeeee eeee eeeeeee α,β-eeeeeeeeeee eeeeeeeee eeee eeee eeeeeeee.[88,88] Mee eeeeeeeee eeeeeeeeee eee eee Meeeeeeee eeeeeeee eee eeeeeeeeeee ee Meeeee 8 eeeeeee e eeeeeee eeeeeee eeeee eeee eee eeeeee eeeeeeeeee, eeeeeeeee eee eeeee eeeeeeeee ee e MMM eeeeeeee eeeeeeeee.[88]
Meeeee 8 Me Meeeeee ee eee Meeeeeeee Meeeeeee eeeee Meeeeee Meeeeeeeee[88]
Meeeeeeeeeee Meeeeeeee
8-(Meeeeeeeee)-8-[(8-eeee-eeeeeeeeeeeeeeeeeee)-88,88-eeeeeeee-8,88-eeeee-8,88-eeeeeeeeeeeee[88.8.8.888,88]eeee-88-ee]-8-eeeeeeee Meeeeee (8):[88]
M eeee ee eeeeeeee 8 (888 ee, 888 µeee) ee eeeee MM8Me8 (88 eM) eee eeeeeee eeee eeeee eeeeeeeeee (888 ee, 8.88 eeee) eee MeMM (8.88 eM, 8.88 eeee). Mee eeeeeee eee eeeeeee ee ee eeeeeeeee. Mee eee eeeeeeeee eeee eeeeeee eeeee eeeeeee eeeeeeee eee eee eeeeeee eee eeeeeeee ee eeeeee eeeeeeeeeeeeee (eeeeee eee, eeeeeee/eeeeeee 8:8 ee 8:8 eeeeeeee) ee eeeeee eee eeeeeee ee e eeeee eeeee; eeeee: 888 ee (88%).
References
[5] | Meeee, M. M.; Meeeeeee, M., M. Me. Meee. Mee., (8888) 88, 888. |
[8] | Meeńeeee, M.; Meeeóeeee, M.; Młeżeeeeeee, M.; Meeeeeee, M.; Meeeee, M.; Meeeeeeeee, M., Meeeee. Mee. Meee., (8888) 88, 8888. |
[9] | Meeeeeeeeee, M. M.; Meeeeeee, M.; Meeeeeeeee, M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[10] | Meeee, M.; Meeee, M.; Meee, M., Mee. M. Mee. Meee., (8888), 8888. |
[11] | Meeee, M.; Meeee, M.; Meee, M.; Meeeee, M., Meeeeeeeeee Meee., (8888) 88, 888. |
[12] | Mee, M.; Meeee, M., Mee. Meee., (8888) 8, 8888. |
[13] | Meeeee, M.; Meeeeeeeee, M.; Meeeee, M.; Meeeeee, M., Meeeeeeee, (8888), 888. |
[14] | Meeeee, M.; Mee, M., Meeeee Meeeeee Mee. Meee., (8888) 888, 888. |
[15] | Meeeeee, M.; Me, M. M.; Meeee, M.; Meeeeeee, M.; Meeeeee, M.; Meee, M.; Meeeeeeeee, M. M.; Meeee, M.; Meeee, M.; Meeee, M., Meee. Meeeee. (Meeeeeeee), (8888), 8888. |
[16] | Meeeeee, M. M.; Meeeeee, M.; Meeee, M. M. M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[18] | Meeee, M.; Meeeee, M.; Meee, M., Meee. Meeeee. (Meeeeeeee), (8888), 888. |
[19] | Meeeee, M., Meeeeeeeeee Meee., (8888) 88, 8888. |
[20] | Me, M.; Mee, M.; Mee, M. M.; Meeee, M. M., Meee. Meee. Meee., (8888) 88, 888. |
[21] | Meeeee, M. M.; Meeee, M.; Meeeeeee, M., Meeeeeeee M. Mee. Meee., (8888) 8, 8888. |
[22] | Meeáeeeee, M.; Meeeeeeeeee, M.; Me, M.; Meeeeeee, M.; Meeeeee, M.; Meeeeeeeeeeeeee, M.; Meee, M.-M.; Meeeeee, M. M., Mee. Meee., (8888) 8, 8888. |