Science of Synthesis

Patel, R. N., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 3, 406.

Numerous marketed treatments exist for anxiety and depression, which are psychiatric disorders that constitute a major health concern worldwide. However, there remains a need for agents that have increased effectiveness and/or reduced side-effects.[‌12‌–‌14‌] Corticotropin releasing factor-1 (CRF-1) receptor antagonists have been proposed as pharmacological treatments for depression, anxiety, and stress disorders.[‌12‌–‌15‌]

(M)-eee-Meeeeeeeee [(M)-‌8‌] eee (M)-8-eeeeeeeeeeeeeeeeeeeee [(M)-‌8‌] eee eee eeeeee eeeeeeeeeeeee eee eee eeeeeeeee ee MMM-8 eeeeeeee eeeeeeeeeee eeee ee ‌8‌ (‌Meeeee 8‌),[‌88‌,‌88‌] eee eeee eeee eeeeeeee ee eeeeeeeee eeeeeeeeee eeeeeeeee.[‌88‌] Meee, eeeeeeeee eeeeeee eeee eeeeeeeeee ee eeeeeeee eeeeeee eee eee eeeeeeeeeee ee eee (M)-eeeeee eeee eee eeeeeeeeeeeee eeeeeeeee eeee ee (M)-eeeeeeee eeeeeeeeeeee; eeeeeee eeeeeee ee Meeeeeee eeeeeeeeee eeeee eeee eeeeeee eeee eeeeeeee eeee eeeee ee eeee eee eeeeeee eeeeeeee. Me eeeeeee ee eee eeee eeeeee (Meeeeeee eeeeeeeeee MM8888) eee eeeeeee, eee ee eee eeeeeeeeee eeee eee eeeeeeee ee e eeeeeeeeeeeeee eeeeeee eeeeeeeee eeeeeeee ee eee eeeee eeeeeeee eee eeeeeeeee 8′-eeeeeeeee ee e eeeeeeee. Meeeeee eeeeeee ee (M)-eee-eeeeeeeeee [(M)-‌8‌] eee (M)-8-eeeeeeeeeeeeeeeeeeeee [(M)-‌8‌] eeee eeeeeeee eeeee eeeee eeeee ee Meeeeeee eeeeeeeeee MM8888. Mee eeeeeeeeeeee eee eeeeeeeeeeee eeeeee eee eeeeeeeee ee M. eeee MM88 888. Me eeeeeeee ee eee eeeeeee eeeee Meeeeeee eeeeeeeeee, eM eeeeeee eee eeeeeeee eeee eeee eee eeeeeeeee eee eee eeeeeeeeee ee eee-eeeeeeeeee, eee eee eeeeeeeeeee eeeee eee eee eeeeeee eeeeee eeeeeeee. Meee eeeee-ee, eeeeeeeeee ee eee-eeeeeeeeee (8.88 M) eeeee eeeee eeeee ee M. eeee MM88 888 eeeeeeee (M)-eee-eeeeeeeeee [(M)-‌8‌; ee eee eeeeeeeeeeeee eeeeeeee eeee eeee] ee 88.8% eeeee (88.8% ee). (M)-eee-Meeeeeeeee eeeee ee eeeeeeee ee eee eeee eeee eeeee ee eeeeeeeeeee eeeeeeeee eeeeee.[‌88‌]

‌Meeeee 8‌ M MMM-8 Meeeeeee Meeeeeeeee eee Meeeeeeee ee (M)-eee-Meeeeeeeee eee (M)-8-Meeeeeeeeeeeeeeeeeeee ee Meeeeeeee Meeeeeeeeeeeee[‌88‌]

Meeeeeeeeeee Meeeeeeee

(M)-eee-Meeeeeeeee [(M)-‌8‌]; Meeeeee Meeeeeeee:[‌88‌]

M 88 eM eeeeeeeee eeeeeeeee eeeeee eeee (8 M, eM 8) eee eeeee ee eeeeee M. eeee eeeee ee eeeeee MM88 888 (888 e). Meeee eeeeeee, eee eeeee eeee eeeeeeeee eeee ee Meeeeeeeeee eeeeeeeeeee. M8M (88 M) eee eeeee ee e eeeeeeee 88-M eeeeeee, eeeeeeee eeee e eeeeeee eee eM eeeeeeeee. Meeeeeee eee eeeeeee ee 888 eee ee 88 °M. Meeee M8MM8 (888 eM, 8.88 eee) eee eeeee ee eee eeeeeee eeeeeeee ee eeeeeee eee-eeeeeeeeee (eee-‌8‌; 888 e, 88.88 eee) eee eeeeeeee eee eeeeeeeee. Mee eM eee eeeeeeee ee 8.8 eeee eeeee M8MM8 (ee. 88 eM) eee eee eeee eeeeeee ee eeee ee 88 °M. Meeeee eeeeeeee (888 e, 8.88 eee) eee eeeee ee eee eeeeeee, eeeeeeee ee eee M. eeee eeee eeeeeeeeee. Mee eM eee eeeeeeee ee 8.8 eeee eeeee M8MM8 eee eee eeeee eeeeee eee eeeeeee ee 88 M eeee M8M. Mee eeeeeeee eee eee ee 88 °M, 888 eee, eM 8. Me eeeeeee eeeeeeeeee ee eeeeeee ee eM eee eeeeeeeee. Mee eeeeeeee eee eeeeeeeee eeeee >88% ee (88 e). Mee eeeeeee eee eeeeeeee ee eM 88 eeee 88% MeMM eeee (8888 e, 88 M). Mee Meeeeee eeeeeeee (888 eM) eee eeeee eee eee eeeeee eeeeeeeeeee eee eeeeeeeee ee 888 °M ee eeeeeee ee 8 eee. MMM 8888 eeeeeeee (888 eM) eee eeeee ee eeeeee ee eeeeeee eeeeeee. Meeeeeeeee eee eeeeeeeee eeeee eee eeeeeeeeeee eee eeeeee ee ~888 °M. Meeeeeeeee 888-eM eeeeeeeee eeee eeeeeeeee, eeeeeeeee eeee eeee 8 M M8MM8 ee eM 8~8 eeeee eee eeeeeeee ee eee-eeeeeeeeee ee eee eeeeeeeeee eee eeeeeeeeeeeee. Mee eeeeeeeeee eeeeeeeee eeeeeeeeee eeeeeeeeeee eee-eeeeeeeeee eeee eeeeeeee, eeeeee ee ee eee eeee eee eeeeeeee ee eM 8.8 eeee 88% M8MM8 (8.88 M) ee eeee e eeee eeee eee eeeeeeeeeee eeeeeeee eeeee 88 °M. Mee eeeeeeeeeee eeeeeeeeee eee eeeeeeeeeeee eeeee eeeeee, eeeeee MeMM ee eeeeee M8M eeeeeeeeeeeeee. Meee eee M8M eeeee ee eee eeeeeeeeee eee 8.8% ee eeeee, eee eeeeeee eee eeeeeeee eee eee eeee eeeeee eeee MeMM (888 eM). Mee eeee eee eeeee eeeee eeeeee ee 88 °M ee eeee (M)-eee-eeeeeeeeee · 8.8 M8MM8; eeeee: 888 e (88.8% eeeeeeee eeeee, eeeeeeeeeee eeeeeee eeeee ee 88%); 88.8% ee. Meeee eee eeee eeeeeeeeeee (M)-eeeeeeeeeeee eee eee-8-eeeeeeeeeeeeeeeeeeeee (eee-‌8‌), eeee (M)-8-eeeeeeeeeeeeeeeeeeeee [(M)-‌8‌]; eeeeeeee eeeee: 88% (eeeeeeeeeee eee. 88%); 88% ee.

References