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Please login to access the full content or check if you have access via1.6.5.1.4 Concise, Enantioselective Total Synthesis of (−)-Alstonerine
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Shi, L.; Yang, Z., Science of Synthesis: Applications of Domino Transformations in Organic Synthesis, (2015) 1, 608.
The macroline/sarpagine class of indole alkaloids is a rich source of biologically active natural products, some of which exhibit hypotensive, antiamoebic, and antimalarial activities.[71–73] For example, alstonerine (35) has recently been reported to exhibit cytotoxic activity against two human lung cancer cell lines.[74]
Meeeee 8 Meeeeeeeeeeeeeee Meeee Meeeeeeee ee (−)-Meeeeeeeeee[88]
Meeeee eee ee-eeeeeee eeeeeeeee e eeeeeee, eeeeeeeeeeeeeeee eeeee eeeeeeeee ee (−)-eeeeeeeeeee (88) eeeeeeee eeee e-eeeeeeeeee eeeeeeeee eee Meeeee–Meeee eeeeeeee ee eeeeeeee 88 ee eee eeeeeeeee eeee ee eeee eeeeeeeeeeeeee 88 ee 88% eeeee. Mee eeeeeeee eeeeeee ee eeee eeeeeeeee ee eeee ee ee eee eeeee eeeeeee ee e Meeeee–Meeee eeeeeeee eeeeeee ee eee-eeeeeee eeeeeeee eeeeeeeee ee eeeeee. Meeeeeeee, eeeee eeeeeee eeeeeeeee eeeeeeeeeeeeeee, eeeeeeeee e eeeeeeeee 8,8-eeeee eeeeeeeeeeeeeee eeeeeeee ee eeeeeeeee eeeeeeee eee e eee, eeee eee-eeee eeeeeeee ee eeeeeeeee e eeeeee eeee eeeee, eee eeeeee eeeeeeee (−)-eeeeeeeeeee (88) eee eeeeeeee ee 88 eeeee eeee ee eeeeeee eeeee ee 8.8% (Meeeee 8).[88]
References
[71] | Meeeeeeee, M.; Meeeeeee, M.; Meeeeeeeee, M.; Meeeeee, M., Me Mee Meeeeeeee: Meeeeeeee eee Meeeeee, Meeeeee, M. M., Me.; Meeeeeee: Mee Meeee, (8888); Mee. 88, ee 888–888. |
[72] | Meeeeee, M. M.; Meee, M. M., Me Meeeeeeee: Meeeeeee eee Meeeeeeeee Meeeeeeeeeee, Meeeeeeee, M. M., Me.; Meeeeeee Meeeeee: Mee Meee, (8888); Mee. 8, ee 88–88. |
[73] | Meeeeeeeee, M.; Meeee, M. M.; Meeeee, M. M. M.; Meeeeeee, M. M., Meeeee Mee., (8888) 88, 888. |
[74] | Meeeeeeeee, M.; Mee-Meeeeeeee, M.; Meeee, M. M.; Meeeeeee, M. M., Meeeee Mee., (8888) 88, 888. |
[75] | Meeeee, M. M.; Meeeee, M. M., Mee. Meee., (8888) 8, 8888. |