Science of Synthesis

DiRocco, D. A.; Schultz, D. M., Science of Synthesis: Photocatalysis in Organic Synthesis, (2018) 1, 611.

General Introduction

Since the initial reports of photoredox catalysis, the pharmaceutical industry has been interested in applying these nontraditional bond-forming reactions to access and derivatize biologically active molecules.[‌1‌,‌2‌] While new photoredox methods are continuously being published, ones that exhibit broad tolerance toward polar functional groups and utilize “off the shelf” coupling partners are considered ideal for pharmaceutical development. In an effort to accommodate these desires, industrial–academic collaborations have become an avenue to make photoredox catalysis more accessible to industrial researchers. Specifically, medicinal chemists have benefited from photochemical late-stage functionalization methods that provide direct access to unique analogues from a single advanced pharmaceutical intermediate. In turn, scaling up photochemical transformations through flow platforms[‌3‌] and the development of sustainable photocatalysts have greatly enabled process chemists.[‌4‌]

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References