Science of Synthesis

Svatunek, D.; Houk, K. N., Science of Synthesis: Click Chemistry, (2021) 1, 407.

General Introduction

1,3-Dipolar cycloadditions of alkynes constitute the most prominent class of cycloadditions in the field of click chemistry. There is, however, a range of 1,3-dipolar cycloadditions of alkenes with various dipoles that can be considered click chemistry and are potentially bioorthogonal. In this chapter we explore the advantages and disadvantages of employing alkenes in these reactions, and present recent developments, unique reactivities, and applications in the field of alkene/1,3-dipole additions.

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