Science of Synthesis

Giel, M.-C.; Smedley, C. J.; Moses, J. E., Science of Synthesis: Click Chemistry, (2021) 1, 435.

General Introduction

Sulfur(VI) fluoride exchange (SuFEx) is a new-generation click reaction that was launched by Sharpless and co-workers in 2014. SuFEx is a powerful technology for forging stable covalent linkages with absolute reliability,[‌1‌,‌2‌] exploiting a unique blend of stability and latent reactivity that characterize high-oxidation-state S—F functionalities [e.g., S(VI)]. The advantage of controlled reactivity through catalyst tuning, coupled with the thermodynamic and redox stability of the S—F group, in stark contrast to their more common S—Cl counterparts, are critical features of SuFEx click chemistry.

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References