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DOI:
10.1055/sos-SD-241-00002
Li, Y.; Fang, X.; Wang, Y., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 8.
The latest data shows that the number of carboxylic acids available for purchase is 59 000, but only 24 000 meet the criteria for a “good” building block[1] [“rule of two” (Ro2)[2]]. A good-quality building block for medicinal chemistry could be defined as one typically having a molecular weight no greater than 200 Da, a clogP of less than 2 units, and no more than two hydrogen-bond donors and four hydrogen-bond acceptors. Over 20 000 carboxylic acids are available from commercial sources at a moderate cost of less than $150 per gram.[3]
References
| [1] | Meeeeeeee, M.; Meeeeeeeee, M. M.; Meeeeeeee, M. M.; Meeeeee, M.; Meeeeeeeee, M. M.; Meeeee, M.; Meeee, M. M.; Meeeeee, M.; Meeeee, M., M. Meee. Mee. Meeee., (8888) 88, 8888. |
| [2] | Meeeeeee, M. M.; Meeeee, M. M.; Meeee, M.; Meeee, M. M.; Meeeeeeee, M. M., Meee Meeeeeeee Meeee, (8888) 88, 88. |
| [3] | Meeeeeeeeee, M., MMM Meee. Mee., (8888) 88, 888. |
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