Science of Synthesis

Franzini, R. M., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 425.

The procedure below describes the removal of the MMT protecting group with mild acid, followed by coupling of a carboxylic acid, as shown in ‌Scheme 1‌.

Meeeeeeeeeee Meeeeeeee

Meeeeeee ee Meeeeeeeee Meeee ee MMM-Meeeeeeeeee Meeee-Meeeeeee MMM eee Meeeeeeeee Meeee Meeeeeee (‌Meeeee 8‌); Meeeeee Meeeeeeee:[‌8‌]

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Mee eeeeeeeee MMM eee eeeeeeeee ee M8M (888 µM) eee eeeeeeee ee MMMM [eeeeeee M: 8.8 M eeeeeeeeeeeeeeee eeeeeee (MMMM) eeeeee (eM 8); eeeeeee M: MeMM; 88% ee 88% M ee 8 eee, eeee ee 88% M ee 8 eee]. Meeeeeee MMM eee eeeeeeee ee M-MMM eeee eeeeeeeeeeee.

References