0 Hits

  • Previous / Next

You are using Science Of Synthesis as a Guest.
Please login to access the full content or check if you have access via
4.2.2 Summary and Outlook

DOI: 10.1055/sos-SD-241-00219

Huang, Y.; Li, X.Science of Synthesis: DNA-Encoded Libraries, (20241598.

The use of photo-crosslinkers and other electrophilic covalent linkers has become an important approach in DEL selections. The major advantage of this approach is that it establishes a stable connection between the binders and the target protein, thereby widening the difference between binders and non-binders in the aspect of stability on the target proteins. Thus, DPAL and other crosslinking-based methods are expected to see wide applications in DEL selections, especially against complex biological targets.