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DOI: 10.1055/sos-SD-241-00223

Prati, L.; Lucaroni, L.; Cazzamalli, S.; Neri, D.; Oehler, S.Science of Synthesis: DNA-Encoded Libraries, (20241538.

AAZ+ is a high-affinity carbonic anhydrase IX (CAIX) ligand that has been isolated from an ESAC library.[‌6‌] Such ligands can be used as targeting moiety for the construction of small-molecule–drug conjugates (SMDCs). In this section, we provide a procedure to synthesize AAZ+–ValCit–MMAE (Figure 11).[‌27‌,‌46‌]

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