Science of Synthesis

Mateos-Gil, J.; Fañanás-Mastral, M., Science of Synthesis Knowledge Updates, (2025) 1, 153.

General Introduction

Organolithium reagents are widespread compounds that are commonly used in a range of synthetic transformations and serve as precursors for the preparation of other organometallic reagents. Nevertheless, their high reactivity and strong basicity had traditionally led to them being neglected for direct use as coupling partners in metal-catalyzed C—C bond forming reactions (see Section 8.1). Nowadays the situation is different due to recent advances in the field that have brought these readily available reagents to the forefront of cross-coupling reactions.

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References