Science of Synthesis

Walker, J. C. L., Science of Synthesis Knowledge Updates, (2024) 3, 201.

General Introduction

This is an update to the previous Science of Synthesis chapter on naphthyridines (Section 15.8) compiled by Phuan and Kozlowski,[‌1‌] and it deals with new methods reported for the preparation of naphthyridines since 2005. As in the original chapter, the focus lies on the six isomeric forms of naphthyridine (‌Scheme 1‌). These are 1,5-naphthyridine (‌1‌), 1,6-naphthyridine (‌2‌), 1,7-naphthyridine (‌3‌), 1,8-naphthyridine (‌4‌), 2,6-naphthyridine (‌5‌), and 2,7-naphthyridine (‌6‌). The oxidized forms, such as 1,6-naphthyridin-5-ol (‌7A‌), are also included (‌Scheme 2‌). These species exhibit keto–enol tautomerism with the corresponding keto form (e.g., ‌7B‌).

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References