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22.4.9.2 Amidines (Imidamides) N-Substituted by Metals, Halogens, Oxygen, and Other Heteroatoms (Update 2024)

DOI: 10.1055/sos-SD-122-00164

Huang, H.; Deng, G.-J.; Ji, X.Science of Synthesis Knowledge Updatesearly view.

General Introduction

The amidine (or imidamide) group is an important structural unit of organic molecules, including numerous bioactive naturally occurring products, drugs, pesticides, functional materials, and others. Substituted amidines have the general formula R1C(NR2)NR3R4, where R2, R3, and R4 can be metal or halogen atoms, or amino, hydroxy, or silyl groups, or others. Some of these derivatives are very well established and have their own characteristic names. These compounds have wide applications in the construction of complex functionalized molecules. This review serves as an update to complement the previous Science of Synthesis article on this topic (Section 22.4.9).[‌1‌] Herein, we showcase new synthetic methodologies developed between 2005 and 2022 for the preparation of amidines that are substituted at one of the nitrogen atoms by metals, halogens, oxygen, or other heteroatoms.

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