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2.3 Metal-Free DEL-Compatible C—C Bond Forming Reactions

DOI: 10.1055/sos-SD-241-00046

Wang, Z.; Satz, A. L.Science of Synthesis: DNA Encoded Librariesearly view.

General Introduction

Carboncarbon bonds play a key role in the skeletal diversity of drug-like molecules, and so it follows that DNA-compatible CC bond formation (e.g., Scheme 1) is of high interest to the DNA-encoded chemical library community. In this chapter, we review nearly two decades of metal-free CC bond forming literature applied towards the construction of DNA-encoded libraries (DELs). For metal-promoted DEL-compatible CC bond forming reactions, readers are guided to Section 2.2.

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