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DOI:
10.1055/sos-SD-241-00046
Wang, Z.; Satz, A. L., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 137.
General Introduction
Carbon—carbon bonds play a key role in the skeletal diversity of drug-like molecules, and so it follows that DNA-compatible C—C bond formation (e.g., Scheme 1) is of high interest to the DNA-encoded chemical library community. In this chapter, we review nearly two decades of metal-free C—C bond forming literature applied towards the construction of DNA-encoded libraries (DELs). For metal-promoted DEL-compatible C—C bond forming reactions, readers are guided to Section 2.2.
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