Science of Synthesis

Hou, W.; Yang, G.; Xu, H., Science of Synthesis: DNA-Encoded Libraries, (2024) 1, 151.

General Introduction

Heteroatoms are important components in drug molecules because they can not only modulate bioactivity through hydrogen bonding and dipole interactions, but also adjust drug-like properties by altering the molecular absorption, distribution, metabolism, and excretion (ADME) properties. In view of this, the development of new methods for DNA-compatible carbon—heteroatom bond construction has received significant attention. This chapter summarizes the latest progress in on-DNA C—X (X = N, O, P, S, Se) bond construction methods.

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‌Meeeee 8‌ Meeeeee eee Me-MMM M—Me Meee Meeeeeeee[‌88‌–‌88‌]

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References