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2.4 On-DNA C—X (X = N, O, P, S, Se) Bond Forming Reactions

DOI: 10.1055/sos-SD-241-00055

Hou, W.; Yang, G.; Xu, H.Science of Synthesis: DNA Encoded Librariesearly view.

General Introduction

Heteroatoms are important components in drug molecules because they can not only modulate bioactivity through hydrogen bonding and dipole interactions, but also adjust drug-like properties by altering the molecular absorption, distribution, metabolism, and excretion (ADME) properties. In view of this, the development of new methods for DNA-compatible carbonheteroatom bond construction has received significant attention. This chapter summarizes the latest progress in on-DNA CX (X = N, O, P, S, Se) bond construction methods.

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