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3.2.2.1 Encoded Self-Assembling (Dynamic) Chemical Libraries

DOI: 10.1055/sos-SD-241-00223

Prati, L.; Lucaroni, L.; Cazzamalli, S.; Neri, D.; Oehler, S.Science of Synthesis: DNA-Encoded Libraries, (20241519.

General Introduction

DNA-encoded chemical libraries (DELs) are large collections of compounds, individually linked to specific DNA tags, serving as unique amplifiable identification barcodes. DELs facilitate the synthesis and screening of large numbers of compounds at a time against proteins of pharmaceutical interest.[‌1‌] DELs can be classified as single- and dual-pharmacophore libraries, depending on whether the display of the building blocks occurs at the extremities of one or two complementary strands.

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References


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